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Pregled bibliografske jedinice broj: 1018710

Changes in saliva of dogs with canine leishmaniosis: a proteomic approach

Franco-Martínez, Lorena; Tvarijonaviciute, Asta; Horvatić, Anita; Guillemin, Nicolas; Bernal, Luis Jesús; Barić Rafaj, Renata; Cerón, José Joaquín; Thomas, María del Carmen; López, Manuel C.; Tecles, Fernando et al.
Changes in saliva of dogs with canine leishmaniosis: a proteomic approach // Veterinary parasitology, 272 (2019), 44-52 doi:10.1016/j.vetpar.2019.06.014 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1018710 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Changes in saliva of dogs with canine leishmaniosis: a proteomic approach

Autori
Franco-Martínez, Lorena ; Tvarijonaviciute, Asta ; Horvatić, Anita ; Guillemin, Nicolas ; Bernal, Luis Jesús ; Barić Rafaj, Renata ; Cerón, José Joaquín ; Thomas, María del Carmen ; López, Manuel C. ; Tecles, Fernando ; Martínez-Subiela, Silvia ; Mrljak, Vladimir

Izvornik
Veterinary parasitology (0304-4017) 272 (2019); 44-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biomarkers ; saliva ; leishmaniosis ; dog ; gel-free proteomics ; tandem mass tag

Sažetak
In the present study, a quantitative proteomic approach to study changes in saliva proteins associated with canine leishmaniosis (CanL) was performed. For this, canine salivary proteins were analysed and compared between dogs before (T0) and after (T1) experimental infection with Leishmania infantum by high-throughput label-based quantitative LC–MS/MS proteomic approach and bioinformatic analysis of the in silico inferred interactome protein network was created from the initial list of differential proteins. More than 2000 proteins were identified, and of the 90 differentially expressed proteins between T0 and T1, 12 were down-regulated with log2 fold change lower than −0.5849, and 19 were up- regulated with log2 fold change greater than 0.5849. This study provides evidence of changes in salivary proteome that can occur in canine leishmaniosis and revealed biological pathways in saliva modulated in canine leishmaniosis with potential for further targeted research.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA

Projekti:
EK-FP7-621394 - Upgrading the research performance in molecular medicine at the Faculty of Veterinary Medicine University of Zagreb (VETMEDZG) (EK - FP7-ERAChairs-PilotCall-2013) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb

Profili:

Avatar Url Anita Horvatić (autor)

Avatar Url Vladimir Mrljak (autor)

Avatar Url Renata Barić-Rafaj (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Franco-Martínez, Lorena; Tvarijonaviciute, Asta; Horvatić, Anita; Guillemin, Nicolas; Bernal, Luis Jesús; Barić Rafaj, Renata; Cerón, José Joaquín; Thomas, María del Carmen; López, Manuel C.; Tecles, Fernando et al.
Changes in saliva of dogs with canine leishmaniosis: a proteomic approach // Veterinary parasitology, 272 (2019), 44-52 doi:10.1016/j.vetpar.2019.06.014 (međunarodna recenzija, članak, znanstveni)
Franco-Martínez, L., Tvarijonaviciute, A., Horvatić, A., Guillemin, N., Bernal, L., Barić Rafaj, R., Cerón, J., Thomas, M., López, M. & Tecles, F. (2019) Changes in saliva of dogs with canine leishmaniosis: a proteomic approach. Veterinary parasitology, 272, 44-52 doi:10.1016/j.vetpar.2019.06.014.
@article{article, author = {Franco-Mart\'{\i}nez, Lorena and Tvarijonaviciute, Asta and Horvati\'{c}, Anita and Guillemin, Nicolas and Bernal, Luis Jes\'{u}s and Bari\'{c} Rafaj, Renata and Cer\'{o}n, Jos\'{e} Joaqu\'{\i}n and Thomas, Mar\'{\i}a del Carmen and L\'{o}pez, Manuel C. and Tecles, Fernando and Mart\'{\i}nez-Subiela, Silvia and Mrljak, Vladimir}, year = {2019}, pages = {44-52}, DOI = {10.1016/j.vetpar.2019.06.014}, keywords = {biomarkers, saliva, leishmaniosis, dog, gel-free proteomics, tandem mass tag}, journal = {Veterinary parasitology}, doi = {10.1016/j.vetpar.2019.06.014}, volume = {272}, issn = {0304-4017}, title = {Changes in saliva of dogs with canine leishmaniosis: a proteomic approach}, keyword = {biomarkers, saliva, leishmaniosis, dog, gel-free proteomics, tandem mass tag} }
@article{article, author = {Franco-Mart\'{\i}nez, Lorena and Tvarijonaviciute, Asta and Horvati\'{c}, Anita and Guillemin, Nicolas and Bernal, Luis Jes\'{u}s and Bari\'{c} Rafaj, Renata and Cer\'{o}n, Jos\'{e} Joaqu\'{\i}n and Thomas, Mar\'{\i}a del Carmen and L\'{o}pez, Manuel C. and Tecles, Fernando and Mart\'{\i}nez-Subiela, Silvia and Mrljak, Vladimir}, year = {2019}, pages = {44-52}, DOI = {10.1016/j.vetpar.2019.06.014}, keywords = {biomarkers, saliva, leishmaniosis, dog, gel-free proteomics, tandem mass tag}, journal = {Veterinary parasitology}, doi = {10.1016/j.vetpar.2019.06.014}, volume = {272}, issn = {0304-4017}, title = {Changes in saliva of dogs with canine leishmaniosis: a proteomic approach}, keyword = {biomarkers, saliva, leishmaniosis, dog, gel-free proteomics, tandem mass tag} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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