Naslov
Mononuclear cobalt, nickel and copper complexes with glycinamide: structural properties and biological activity

Autori
Prugovečki, Biserka ; Vušak, Darko ; Smrečki, Neven ; Kralj, Marijeta ; Uzelac, Lidija ; Matković-Čalogović, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
32nd European Crystallographic Meeting : book of abstracts / - Beč : European Crystallographic Meeting, 2019, 546-546

Skup
32nd European Crystallographic Meeting

Mjesto i datum
Beč, Austrija, 18.08.2019. - 23.08.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glycinamide ; cobalt ; nickel ; copper

Sažetak
Glycinamide (HL) is the simplest amino acid amide, cheap and available and easily synthesized. In the CSD there are only six structures containing the glycinamide fragment: glycinamide hydrochloride, two rhodium complexes, a bimetallic (Mn, Cr) ferrimagnet, a ruthenium complex and an iridium complex. As a part of our ongoing research on investigation of metal complexes with amino acids and their derivatives, we report synthesis, solid-state characterization and antiproliferative activity of cobalt, nickel and copper complexes with glycinamide. In the cobalt(II) and nickel(II) complexes [M(H2O)2(HL)2]X2 (M = Co, Ni ; X = Cl, Br/Cl, I), the metal(II) cation is octahedrally coordinated by two glycinamide molecules in a cis-fashion and by two water molecules. In [CuCl2(HL)2] and [CuBr1.3Cl0.7(HL)2] the octahedral coordination environment around the Cu(II) ions consists of two N, O-bidentate glycinamide ligands in a trans-fashion and two halide ions. [Co(H2O)2(HL)2]Cl2 and [CuCl2(HL)2] showed moderate antiproliferative activity and selectivity towards MCF-7 cell lines. The research was supported by the Croatian Science Foundation, project “Essential metal ions in Helicobacter pylori proteins and model complexes structure and function/property” (HRZZ-IP-2014-09-4274).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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