Naslov
CLINOPODIUM VULGARE L. ESSENTIAL OIL – CHEMICAL COMPOSITION, CHOLINESTERASE INHIBITION AND ANTIOXIDANT POTENTIAL

Autori
Mejra Bektašević, Olivera Politeo, Ivana Carev

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstract / Novak, Johaness. Stappen, Iris - Beč, 2019, 102-102

Skup
50th International Symposium on Essential Oils

Mjesto i datum
Beč, Austrija, 09.09.2019. - 11.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Clinopodium vulgare L., essential oil, antioxidant activity, cholinesterase inhibition

Sažetak
Clinopodium vulgare L. (Lamiaceae) is medicinal plant characteristic for traditional medicine of Bosnia and Herzegovina (BiH). In BiH Clinopodium vulgare L. is used in the treatment of digestive disorders [1], while in traditional medicine of other countries this plant is used for treatment of diabetes, cancer and viral skin diseases [2, 3]. Medicinal plants are rich in bioactive compounds. Oxidative stress is related with etiology and pathogenesis of many chronic diseases and bioactive antioxidant compounds may have an important role in their prevention and treatment. Ihibitors of cholinesterase have important role in the treatment of Alzheimer’s disease and many components of essential oils and plants extracts are being tested as potential cholinesterase inhibitors. In this work chemical composition of Clinopodium vulgare L. essential oil, from the area of BiH, is determined using GC/MS and GC/FID technique. Inhibition of acetylcholinesterase and butyrylcholinesterase was tested by Ellman’s method [4], while antioxidant potential was tested using DPPH and FRAP method. The results of the analysis of essential oil showed that analyzed oil is rich in sesquiterpenes. The major compounds were epi-bicyclosesquiphelandrene (18.1%), α-gurjunene (10.9%) and hexadecanoic acid (10.5%). Compared to standard compounds BHA and vitamin C, Clinopodium vulgare L. essential oil showed moderate antioxidative potential, as well as moderate ability to inhibit the enzymes acetylcholinesterase (40%) and butyrylcholinesterase (23%) in concentration of 1 g/L in stock solution.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA