Naslov
Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs

Autori
Torić, Jelena ; Karković Marković, Ana ; Jakobušić Brala, Cvijeta ; Barbarić, Monika

Izvornik
Acta pharmaceutica (1330-0075) 69 (2019); 461-482

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
olive polyphenols, anticancer, chemoprotective, synergism

Sažetak
Cancer presents one of the main causes of death in the world. The cancer treatment includes the administration of one or more anticancer drugs, commonly known as chemotherapy. The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. One approach to the issue is chemoprevention and another one is discovery of more effective drugs or drug combinations, including combinations with polyphenols. Olive oil polyphenols (OOPs), especially hydroxytyrosol (HTyr), tyrosol (Tyr) and their derivatives oleuropein (Ole), oleacein and oleocanthal (Oc) express anticancer activity on different cancer models. Recent studies report that phenolic extract of virgin olive oil may be more effective than individual phenolic compounds. Also, there is a growing body of evidence about the combined treatment of OOPs with various anticancer drugs, such as cisplatin, tamoxifen, doxorubicin and others. These novel approaches may present a advanced strategy in prevention and treatment of cancer.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA