Naslov
A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms

Autori
Kruljac, Ivan ; Vurnek, Ivan ; Maasberg, Sebastian ; Kust, Davor ; Blaslov, Kristina ; Ladika Davidović, Blaženka ; Štefanović, Mario ; Demirović, Alma ; Bišćanin, Alen ; Filipović-Čugura, Jakša ; Marić Brozić, Jasmina ; Pape, Ulrich-Frank ; Vrkljan, Milan

Izvornik
Endocrine (Basingstoke) (1355-008X) 60 (2018), 3; 395-406

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chromogranin A ; comorbidity ; diagnostic accuracy ; score ; neuroendocrine neoplasm

Sažetak
Background Chromogranin A (CgA) is a valuable biomarker for detection and follow-up of patients with neuroendocrine neoplasms (NENs). However, various comorbidities may influence serum CgA, which decreases its diagnostic accuracy. We aimed to investigate which laboratory parameters are independently associated with increased CgA in real- life setting and to develop a scoring system, which could improve the diagnostic accuracy of CgA in detecting patients with NENs. Methods This retrospective study included 55 treatment naïve patients with NENs and160 patients with various comorbidities but without NEN (nonNENs). Scoring system (CgA-score) was developed based on z- scores obtained from receiver operating curve analysis for each parameter that was associated with elevated serum CgA in nonNENs. Results CgA correlated positively with serum BUN, creatinine, α2-globulin, red-cell distribution width, erythrocyte sedimentation rate, plasma glucose and correlated inversely with hemoglobin, thrombocytes and serum albumin. Serum CgA was also associated with the presence of chronic renal failure, arterial hypertension and diabetes and the use of PPI. In the entire study population, CgA showed an area under the curve of 0.656. Aforementioned parameters were used to develop a CgA-score. In a cohort of patients with CgA-score <12.0 (N = 87), serum CgA >156.5 ng/ml had 77.8% sensitivity and 91.5% specificity for detecting NENs (AUC 0.841, 95% CI 0.713–0.969, P < 0.001). Serum CgA had no diagnostic value in detecting NENs in patients with CgA-score >12.0 (AUC 0.554, 95% CI 0.405–0.702, P = 0.430). Conclusions CgA-score encompasses a wide range of comorbidities and represents a promising tool that could improve diagnostic performance of CgA in everyday clinical practice.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA