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Pregled bibliografske jedinice broj: 101576

Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo


Polić, Bojan; Jonjić, Stipan; Pavić, Ivica; Crnković, Irena; Zorica, Irena; Hengel, H.; Lučin, Pero; Koszinowski, Ulrich H.
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo // Journal of general virology, 77 (1996), ( Pt 2 ); 217-225 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 101576 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo

Autori
Polić, Bojan ; Jonjić, Stipan ; Pavić, Ivica ; Crnković, Irena ; Zorica, Irena ; Hengel, H. ; Lučin, Pero ; Koszinowski, Ulrich H.

Izvornik
Journal of general virology (0022-1317) 77 (1996), ( Pt 2 ); 217-225

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MHC class I protein ; Murine cytomegalovirus (MCMV) ; beta 2-microglobulin (beta 2m) ; beta 2m-deficient mice ; beta 2m mutant mice

Sažetak
It has been claimed that MHC class I proteins serve as receptors for murine cytomegalovirus (MCMV) and that this interaction is the most important mechanism for virus entry in most cells. This claim is based on the observation that the MHC haplotype contributes to the susceptibility to cytomegalovirus (CMV) infection in vivo. Results from in vitro studies support the concept that stable expression of correctly folded MHC class I molecules contributes to infection, since the individual properties of MHC class I alleles, the availability of beta 2-microglobulin (beta 2m) and also the degree of peptide charging of the MHC class I heavy chain beta 2m heterodimers determined the infection phenotype of cell lines. To assess the biological relevance of proper MHC class I expression we investigated CMV infection in beta 2m-deficient mice which fail to express ternary MHC class I complexes and lack peripheral CD8+ T lymphocytes. We found that organ virus titres and virus clearance kinetics were not altered in beta 2m mutant mice. In addition, there was no indication of diminished virus propagation in beta 2m-/- embryonic fibroblasts. beta 2m-/- mice suffered from the lack of CD8+ T lymphocytes that was partially compensated for by the function of CD4+ T lymphocytes. An organ-specific anti- virus function of natural killer (NK) cells was observed, independent from the beta 2m deletion. The immune control unique for salivary gland infection was maintained. From the data presented here, we confirm the role of MHC class I molecules in the immune surveillance of CMV infection but question the biological impact of correct MHC class I complexes for productive infection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekti:
062006

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Irena Crnković (autor)

Avatar Url Ivica Pavić (autor)

Avatar Url Irena Mišurac (autor)

Avatar Url Stipan Jonjić (autor)

Avatar Url Pero Lučin (autor)

Avatar Url Bojan Polić (autor)


Citiraj ovu publikaciju:

Polić, Bojan; Jonjić, Stipan; Pavić, Ivica; Crnković, Irena; Zorica, Irena; Hengel, H.; Lučin, Pero; Koszinowski, Ulrich H.
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo // Journal of general virology, 77 (1996), ( Pt 2 ); 217-225 (međunarodna recenzija, članak, znanstveni)
Polić, B., Jonjić, S., Pavić, I., Crnković, I., Zorica, I., Hengel, H., Lučin, P. & Koszinowski, U. (1996) Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo. Journal of general virology, 77 (( Pt 2 )), 217-225.
@article{article, author = {Poli\'{c}, Bojan and Jonji\'{c}, Stipan and Pavi\'{c}, Ivica and Crnkovi\'{c}, Irena and Zorica, Irena and Hengel, H. and Lu\v{c}in, Pero and Koszinowski, Ulrich H.}, year = {1996}, pages = {217-225}, keywords = {MHC class I protein, Murine cytomegalovirus (MCMV), beta 2-microglobulin (beta 2m), beta 2m-deficient mice, beta 2m mutant mice}, journal = {Journal of general virology}, volume = {77}, number = {( Pt 2 )}, issn = {0022-1317}, title = {Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo}, keyword = {MHC class I protein, Murine cytomegalovirus (MCMV), beta 2-microglobulin (beta 2m), beta 2m-deficient mice, beta 2m mutant mice} }
@article{article, author = {Poli\'{c}, Bojan and Jonji\'{c}, Stipan and Pavi\'{c}, Ivica and Crnkovi\'{c}, Irena and Zorica, Irena and Hengel, H. and Lu\v{c}in, Pero and Koszinowski, Ulrich H.}, year = {1996}, pages = {217-225}, keywords = {MHC class I protein, Murine cytomegalovirus (MCMV), beta 2-microglobulin (beta 2m), beta 2m-deficient mice, beta 2m mutant mice}, journal = {Journal of general virology}, volume = {77}, number = {( Pt 2 )}, issn = {0022-1317}, title = {Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo}, keyword = {MHC class I protein, Murine cytomegalovirus (MCMV), beta 2-microglobulin (beta 2m), beta 2m-deficient mice, beta 2m mutant mice} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Index Medicus
  • PubMed





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