Pregled bibliografske jedinice broj: 101576
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivo // Journal of general virology, 77 (1996), ( Pt 2 ); 217-225 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 101576 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Lack of MHC class I complex expression has no
effect on spread and control of cytomegalovirus
infection in vivo
Autori
Polić, Bojan ; Jonjić, Stipan ; Pavić, Ivica ; Crnković, Irena ; Zorica, Irena ; Hengel, H. ; Lučin, Pero ; Koszinowski, Ulrich H.
Izvornik
Journal of general virology (0022-1317) 77
(1996), ( Pt 2 );
217-225
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
MHC class I protein ; Murine cytomegalovirus (MCMV) ; beta 2-microglobulin (beta 2m) ; beta 2m-deficient mice ; beta 2m mutant mice
Sažetak
It has been claimed that MHC class I proteins serve as receptors for murine cytomegalovirus (MCMV) and that this interaction is the most important mechanism for virus entry in most cells. This claim is based on the observation that the MHC haplotype contributes to the susceptibility to cytomegalovirus (CMV) infection in vivo. Results from in vitro studies support the concept that stable expression of correctly folded MHC class I molecules contributes to infection, since the individual properties of MHC class I alleles, the availability of beta 2-microglobulin (beta 2m) and also the degree of peptide charging of the MHC class I heavy chain beta 2m heterodimers determined the infection phenotype of cell lines. To assess the biological relevance of proper MHC class I expression we investigated CMV infection in beta 2m-deficient mice which fail to express ternary MHC class I complexes and lack peripheral CD8+ T lymphocytes. We found that organ virus titres and virus clearance kinetics were not altered in beta 2m mutant mice. In addition, there was no indication of diminished virus propagation in beta 2m-/- embryonic fibroblasts. beta 2m-/- mice suffered from the lack of CD8+ T lymphocytes that was partially compensated for by the function of CD4+ T lymphocytes. An organ-specific anti- virus function of natural killer (NK) cells was observed, independent from the beta 2m deletion. The immune control unique for salivary gland infection was maintained. From the data presented here, we confirm the role of MHC class I molecules in the immune surveillance of CMV infection but question the biological impact of correct MHC class I complexes for productive infection.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina
POVEZANOST RADA
Projekti:
062006
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Irena Crnković
(autor)
Ivica Pavić
(autor)
Irena Mišurac
(autor)
Stipan Jonjić
(autor)
Pero Lučin
(autor)
Bojan Polić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Index Medicus
- PubMed