Naslov
Application of spectroscopic methods in quality control of pharmaceutical products and counterfeits

Autori
Pitarević, Lovorka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR Book of Abstracts / Namijesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2019, 43-43

ISBN
978-953-6076-56-7

Skup
Adriatic NMR 2019

Mjesto i datum
Mali Ston, Hrvatska, 06.06.2019. - 09.06.2019

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Recenziran

Ključne riječi
spectroscopic methods, quality control, pharmaceutical products

Sažetak
Quality control of pharmaceutical products within the shelf-life is accomplished by using diverse analytical methods that are validated by manufacturer and approved by the national authority. In EU, laboratories in charge of monitoring the quality of pharmaceutical products are usually a part of national governments in EU which is also the case in Croatia. Traditionally, qualitative and quantitative analysis of active pharmaceutical ingredient (API) and impurities in products depends heavily on chromatographic methods, i.e. HPLC. Analytical approach using orthogonal analytical methods in identification and structural analysis of pharmaceutical substance is on the other hand commonly used during its production. Among other methods, nuclear magnetic resonance (NMR) plays vital role both in structural analysis of APIs and impurities and as well in analysis of counterfeits. So far NMR is not method of choice in analysis of finished pharmaceutical products during a routine quality control due to several different reasons. Never the less, NMR is irreplaceable analytical “tool” when considering any structural analysis in pharmaceutical samples and it comes very handy when challenging samples like counterfeits are set up on us.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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