Pregled bibliografske jedinice broj: 1015368
Crystallization of a Pharmaceutical Co-crystal by Advanced Supersaturation Control
Crystallization of a Pharmaceutical Co-crystal by Advanced Supersaturation Control // 26. Hrvatski skup kemičara i kemijskih inženjera / Galić, Nives ; Rogošić, Marko (ur.).
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019. str. 187-187 (poster, recenziran, sažetak, znanstveni)
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Naslov
Crystallization of a Pharmaceutical Co-crystal by Advanced Supersaturation Control
Autori
Šahnić, Damir ; Kišiček, Dejan ; Dorić, Hrvoje ; Mohler, Ivan ; Bolf, Nenad
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
26. Hrvatski skup kemičara i kemijskih inženjera
/ Galić, Nives ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2019, 187-187
Skup
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog
Mjesto i datum
Šibenik, Hrvatska, 09.04.2019. - 12.04.2019
Vrsta sudjelovanja
Poster
Vrsta recenzije
Recenziran
Ključne riječi
crystalization, process monitoring, process control, supersaturation control, ATR-UV/Vis spectroscopy, PLRS
Sažetak
In situ monitoring and control of crystallization processes is receiving more and more interest in the pharmaceutical and specialty chemicals industries over the past decade [1]. Physical characteristics of APIs such as the polymorphic form, morphology and particle size distribution which are important for subsequent downstream processing are determined by the crystallization process. By manipulating the supersaturation level as the driving force for crystallization, different outcomes with respect to the aforementioned characteristics can be achieved. To that end, robust control strategies of crystallization processes using supersaturation control, achieved by the combined use of Process Analytical Technologies (PATs) and chemometrics can be developed and applied to obtain the desired physical characteristics of APIs [2]. The development of a quantitative in-line ATR- UV/Vis spectroscopic method for solute concentration monitoring during a crystallization process of an API co-crystal is described. The method is comprised of a chemometric PLSR calibration model used for solute concentration calculation from acquired spectra and actual temperatures. The use of this method together with the reactor temperature control achieved by applying feedback supersaturation control (C-control) during the course of a seeded cooling crystallization experiment is also described. Data acquisition for the model development, data preprocessing, model building and C-control was performed with the aid of a proprietary, in-house developed software suite, CrystCal. The developed method proved to be a robust and fast way to monitor the solute concentration in-situ, thereby enabling the C-control system to cool the crystallization mixture while keeping the supersaturation at a desired level. The developed system can be used for other target supersaturation levels and has potential for application on other crystallization systems.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kemijsko inženjerstvo
POVEZANOST RADA
Ustanove:
Pliva-Istraživački institut,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb