Naslov
The non-covalent interaction plots of U6 internal stem-loop domain

Autori
Mihaljević, Frano ; Pilepić, Viktor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, znanstveni

Skup
From Solid State to Biophysics IX

Mjesto i datum
Cavtat, Hrvatska, 16.06.2018. - 23.06.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
non-covalent interactions, U6, snRNA

Sažetak
U6 is the most conserved non-coding small nuclear RNA fragment involved as a key component in the active site of the spliceosome assembly, large RNA-protein complex that catalyzes the removal of introns from eukaryotic precursor messenger RNA [1, 2]. Before being incorporated into the spliceosome, U6 undergoes the intramolecular stem-loop (ISL) conformational change [3, 4]. This flipping conformational switch is of importance for regulating the entire process and includes a corresponding reorganization of base pairing [1-4]. Here, we presented the non-covalent interaction (NCI) plots [5] of U6 fragments to investigate intermolecular stacking interactions, hydrogen bonds and other non-covalent interactions that need to be reorganized in the course of complex dynamic motion and internal conformational change of U6 fragment. The obtained results could be of importance in studies of RNA conformational dynamics.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA