Naslov
Red deer fascioloidosis – a model for host- parasite interaction

Autori
Konjević, Dean ; Bujanić, Miljenko ; Martinković, Franjo ; Arbanasić, Haidi ; Bužan, Elena ; Galov, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Clinical Pathology and Laboratory Medicine / - London : Delhi : Allied Academics, 2019, 13-13

Skup
2nd International Conference on Pathology and Surgical Pathology

Mjesto i datum
Pariz, Francuska, 05.07.2019. - 06.07.2019

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
red deer, Fascioloides magna, MHC genes, host-parasite interactions

Sažetak
Fascioloidosis is a parasitic disease caused by non-native parasite Fascioloides magna. F. magna originally parasitize in the North American deer species. It was introduced to Europe at least twice, forming the three foci of infection: Italian, Czech and Danubian. The latter two gave origin to other, newly formed areas, including the Croatian one. F. magna was detected in Croatia in 2001 and since then have spread to the majority of its lowland areas. The fact that F. magna is a non-native parasite enables us to observe development of host- parasite interactions, but also to create conditions of case-control study in the wild, large mammal population. In this research we aimed to compare variability and presence of specific alleles of MHC class II – DRB exon 2 in relation to F. magna infection. A total of 117 red deer livers and faecal samples originating from lowland (Baranja, Lipovljani and Spačva) and mountain area (Gorski Kotar) were collected. Of them, based on location and parasitological analysis, 46 individuals were selected and tissue samples were sent for analysis using Next Generation Sequencing (NGS). We have detected 44 DRB alleles (2-4 alleles per individual). Four alleles were already known (our references - DRB_NS36, DRB_NS38, DRBref01 i DRBref02). Statistically significant difference was detected in the level of infection in the case of animals with DRB_ref01 and DRB_ref06 alleles (χ2 = 0, 939, p = 0, 332). This implicates on a potential development of host-parasite interaction in the case of red deer and Fascioloides magna.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA