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Pregled bibliografske jedinice broj: 1009856

Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction

Tetyczka, Carolin; Hodzic, Aden; Kriechbaum, Manfred; Juraić, Krunoslav; Spirk, Christina; Hartl, Sonja; Pritz, Elisabeth; Leitinger, Gerd; Roblegg, Eva;
Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction // European journal of pharmaceutics and biopharmaceutics, 139 (2019), 153-160 doi:10.1016/j.ejpb.2019.03.017 (međunarodna recenzija, članak, znanstveni)

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Naslov
Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction

Autori
Tetyczka, Carolin ; Hodzic, Aden ; Kriechbaum, Manfred ; Juraić, Krunoslav ; Spirk, Christina ; Hartl, Sonja ; Pritz, Elisabeth ; Leitinger, Gerd ; Roblegg, Eva ;

Izvornik
European journal of pharmaceutics and biopharmaceutics (0939-6411) 139 (2019); 153-160

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nanostructured lipid carriers (NLC) ; Palmitic acid ; Laboratory small and wide angle X-ray scattering ; Synchrotron X-ray diffraction ; Synchrotron small angle X-ray scattering

Sažetak
The development of lipid nanoparticles requires knowledge on the crystalline structure, polymorphic transitions and lipid-drug interactions. This study aimed at introducing advanced techniques to characterize nanostructured lipid carriers (NLC) comprising palmitic acid, oleic acid, stabilizer and Domperidone. Crystallinity of single components and mixtures was investigated by laboratory Small Angle X-ray Scattering (SAXS). NLC were studied with laboratory Small and Wide Angle X-ray Scattering (SWAXS). Photon Correlation Spectroscopy and Freeze Fracture Transmission Electron Microscopy were used to monitor particle size, zeta potential and shape. Stability of NLC was investigated using synchrotron X-ray Diffraction (XRD) and SAXS and laboratory SAXS. Palmitic acid showed a lamellar structure (polymorph C), which was still present after particle preparation. Spherical 300 nm- sized particles with zeta potential values above −30 mV were obtained and Domperidone was incorporated in its amorphous form. During storage, no differences in synchrotron XRD spectra were seen. However, laboratory SAXS measurements showed a second lamellar structure, identified as polymorph B. Synchrotron SAXS tem- perature scans confirmed that polymorph B did not affect the morphology of the encapsulated drug or the shape of NLC. These results highlight the unique capabilities of laboratory and synchrotron X-ray Scattering and Diffraction for improved structural characterization of lipid nanoparticles.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Farmacija



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Krunoslav Juraić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Tetyczka, Carolin; Hodzic, Aden; Kriechbaum, Manfred; Juraić, Krunoslav; Spirk, Christina; Hartl, Sonja; Pritz, Elisabeth; Leitinger, Gerd; Roblegg, Eva;
Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction // European journal of pharmaceutics and biopharmaceutics, 139 (2019), 153-160 doi:10.1016/j.ejpb.2019.03.017 (međunarodna recenzija, članak, znanstveni)
Tetyczka, C., Hodzic, A., Kriechbaum, M., Juraić, K., Spirk, C., Hartl, S., Pritz, E., Leitinger, G., Roblegg, E. & (2019) Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction. European journal of pharmaceutics and biopharmaceutics, 139, 153-160 doi:10.1016/j.ejpb.2019.03.017.
@article{article, author = {Tetyczka, Carolin and Hodzic, Aden and Kriechbaum, Manfred and Jurai\'{c}, Krunoslav and Spirk, Christina and Hartl, Sonja and Pritz, Elisabeth and Leitinger, Gerd and Roblegg, Eva}, year = {2019}, pages = {153-160}, DOI = {10.1016/j.ejpb.2019.03.017}, keywords = {Nanostructured lipid carriers (NLC), Palmitic acid, Laboratory small and wide angle X-ray scattering, Synchrotron X-ray diffraction, Synchrotron small angle X-ray scattering}, journal = {European journal of pharmaceutics and biopharmaceutics}, doi = {10.1016/j.ejpb.2019.03.017}, volume = {139}, issn = {0939-6411}, title = {Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction}, keyword = {Nanostructured lipid carriers (NLC), Palmitic acid, Laboratory small and wide angle X-ray scattering, Synchrotron X-ray diffraction, Synchrotron small angle X-ray scattering} }
@article{article, author = {Tetyczka, Carolin and Hodzic, Aden and Kriechbaum, Manfred and Jurai\'{c}, Krunoslav and Spirk, Christina and Hartl, Sonja and Pritz, Elisabeth and Leitinger, Gerd and Roblegg, Eva}, year = {2019}, pages = {153-160}, DOI = {10.1016/j.ejpb.2019.03.017}, keywords = {Nanostructured lipid carriers (NLC), Palmitic acid, Laboratory small and wide angle X-ray scattering, Synchrotron X-ray diffraction, Synchrotron small angle X-ray scattering}, journal = {European journal of pharmaceutics and biopharmaceutics}, doi = {10.1016/j.ejpb.2019.03.017}, volume = {139}, issn = {0939-6411}, title = {Comprehensive characterization of nanostructured lipid carriers using laboratory and synchrotron X-ray scattering and diffraction}, keyword = {Nanostructured lipid carriers (NLC), Palmitic acid, Laboratory small and wide angle X-ray scattering, Synchrotron X-ray diffraction, Synchrotron small angle X-ray scattering} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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