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Pregled bibliografske jedinice broj: 1009719

Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles


Hranjec, Marijana; Perin, Nataša; Beč, Anja; Persoons, Lentje; Daelemans, Dirk
Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles // Book of Abstracts, Joint Meeting on Medicinal Chemistry, Prague, 2019 / Vinšová, Jarmila (ur.).
Prag: GUARANT International spol. s r.o., 2019. str. 71-71 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles

Autori
Hranjec, Marijana ; Perin, Nataša ; Beč, Anja ; Persoons, Lentje ; Daelemans, Dirk

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts, Joint Meeting on Medicinal Chemistry, Prague, 2019 / Vinšová, Jarmila - Prag : GUARANT International spol. s r.o., 2019, 71-71

ISBN
978-80-907442-0-2

Skup
11th Joint Meeting on Medicinal Chemistry 2019

Mjesto i datum
Prag, Češka Republika, 27.06.2019. - 30.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acrylonitriles, benzimidazoles, antiproliferative activity

Sažetak
Small heteroaromatic molecules, like nitrogen- containing heterocycles play an important role in medicinal chemistry due to variety of their possible chemical, pharmacological and industrial applications. Benzimidazole structural motifs, as an important bioactive heterocyclic building block in medicinal chemistry, are widely incorporated in the structure of numerous natural or synthetic medical and biochemical molecules possessing versatile biological features.[1, 2] Within this work, we would like to present the synthesis and biological activity of novel N- substituted benzimidazole based acrylonitriles. For the synthesis of novel compounds we have used methods of classical linear organic synthesis as well as microwave assisted synthesis starting from aromatic benzaldehydes and substituted 1, 2- phenylenediamnies.[3] All newly prepared compounds were tested for their antiproliferative activity in vitro on nine human cancer as well as non cancerous cell lines. Some of compounds showed strong and selective antiproliferative activity in submicromolar range of IC50 concentrations. Additional experiments showed that some compounds did not affect normal cells. Mechanism of action studies demonstrated that two most active compounds inhibited the polymerisation of tubuline.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-4379 - Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa (AntioxPot) (Hranjec, Marijana, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Anja Beč (autor)

Avatar Url Nataša Perin (autor)

Avatar Url Marijana Hranjec (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Hranjec, Marijana; Perin, Nataša; Beč, Anja; Persoons, Lentje; Daelemans, Dirk
Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles // Book of Abstracts, Joint Meeting on Medicinal Chemistry, Prague, 2019 / Vinšová, Jarmila (ur.).
Prag: GUARANT International spol. s r.o., 2019. str. 71-71 (poster, međunarodna recenzija, sažetak, znanstveni)
Hranjec, M., Perin, N., Beč, A., Persoons, L. & Daelemans, D. (2019) Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles. U: Vinšová, J. (ur.)Book of Abstracts, Joint Meeting on Medicinal Chemistry, Prague, 2019.
@article{article, author = {Hranjec, Marijana and Perin, Nata\v{s}a and Be\v{c}, Anja and Persoons, Lentje and Daelemans, Dirk}, editor = {Vin\v{s}ov\'{a}, J.}, year = {2019}, pages = {71-71}, keywords = {acrylonitriles, benzimidazoles, antiproliferative activity}, isbn = {978-80-907442-0-2}, title = {Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles}, keyword = {acrylonitriles, benzimidazoles, antiproliferative activity}, publisher = {GUARANT International spol. s r.o.}, publisherplace = {Prag, \v{C}e\v{s}ka Republika} }
@article{article, author = {Hranjec, Marijana and Perin, Nata\v{s}a and Be\v{c}, Anja and Persoons, Lentje and Daelemans, Dirk}, editor = {Vin\v{s}ov\'{a}, J.}, year = {2019}, pages = {71-71}, keywords = {acrylonitriles, benzimidazoles, antiproliferative activity}, isbn = {978-80-907442-0-2}, title = {Synthesis and biological activity of novel N- substituted benzimidazole acrylonitriles}, keyword = {acrylonitriles, benzimidazoles, antiproliferative activity}, publisher = {GUARANT International spol. s r.o.}, publisherplace = {Prag, \v{C}e\v{s}ka Republika} }




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