Naslov
Possible mechanisms of immunotherapy in recurrent spontaneous aborters:analysis of T-helper (Th)1 cytokines

Autori
Humar, Ines ; Duić, Željko ; Kaštelan, Andrija

Izvornik
European Journal of Immunogenetics (0960-7420) 28 (2001), 2;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
T-helper; cytokines; spontaneous aborters

Sažetak
Normal pregnancy is characterized by lack of strong maternal cell-mediated anti-fetal immunity and dominant humoral immune response. Since certain cytokines are propitious to the success of pregnancy, like T-helper (Th) 2 cytokines, conversely concentration Th-1 type cytokines interleukin(IL)-2, tumour necrosis factor (TNF)-alpha, TNF-ß and interferon-gamma are potentially harmful to pregnancy. Since 1995 31 women with history of unexplained three and more recurrent spontaneous abortion (RSA) were treated with intravenous immunoglobulin(IVIG) in the prevention of RSA. The aim of this study was to compare the concentration of Th-1 cytokines produced by women undergoing RSA with those produced during normal pregnancy and IVIG treated in similar gestation stage. The birth of child was considered a successful outcome. For women with primary RSA the success rates were 77%. Significantly increased concentration of the TNF- alpha were found in RSA as compared with successful pregnancy. In abortion -prone women who had a successful pregnancy, lower concentrations of TNF-alpha were found as compared with abortion -prone women who had another abortion, supporting the notion that TH-1 are associated with successful and unsuccessful pregnancy respectively.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA