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Pregled bibliografske jedinice broj: 1008548

Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection

Stojanovic, Bojana; Milovanovic, Jelena; Arsenijevic, Aleksandar; Stojanovic, Bojan; Strazic Geljic, Ivana; Arsenijevic, Nebojsa; Jonjic, Stipan; Lukic, Miodrag L.; Milovanovic, Marija
Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection // Frontiers in Microbiology, 10 (2019), 185, 13 doi:10.3389/fmicb.2019.00185 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1008548 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection

Autori
Stojanovic, Bojana ; Milovanovic, Jelena ; Arsenijevic, Aleksandar ; Stojanovic, Bojan ; Strazic Geljic, Ivana ; Arsenijevic, Nebojsa ; Jonjic, Stipan ; Lukic, Miodrag L. ; Milovanovic, Marija

Izvornik
Frontiers in Microbiology (1664-302X) 10 (2019); 185, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
galectin-3 ; hepatitis ; murine cytomegalovirus infection ; TNF-α ; hepatocyte death

Sažetak
Galectin-3 (Gal-3) has a role in multiple inflammatory pathways. Various, opposite roles of Gal-3 in liver diseases have been described but there are no data about the role of Gal-3 in development of hepatitis induced with cytomegalovirus infection. In this study we aimed to clarify the role of Gal-3 in murine cytomegalovirus (MCMV)-induced hepatitis by using Gal-3–deficient (Gal-3 KO) mice. Here we provide the evidence that Gal-3 has the protective role in MCMV- induced hepatitis. Enhanced hepatitis manifested by more inflammatory and necrotic foci and serum level of ALT, enhanced apoptosis and necroptosis of hepatocytes and enhanced viral replication were detected in MCMV-infected Gal-3 deficient mice. NK cells does not contribute to more severe liver damage in MCMV-infected Gal-3 KO mice. Enhanced expression of TNF-α in the hepatocytes of Gal-3 KO mice after MCMV infection, abrogated hepatocyte death, and attenuated inflammation in the livers of Gal-3 KO mice after TNF-α blockade suggest that TNF-α plays the role in enhanced disease in Gal-3 deficient animals. Treatment with recombinant Gal-3 reduces inflammation and especially necrosis of hepatocytes in the livers of MCMV-infected Gal-3 KO mice. Our data highlight the protective role of Gal-3 in MCMV-induced hepatitis by attenuation of TNF-α-mediated death of hepatocytes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Ivana Stražić Geljić (autor)

Avatar Url Stipan Jonjić (autor)

Poveznice na cjeloviti tekst rada:

doi www.frontiersin.org www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Stojanovic, Bojana; Milovanovic, Jelena; Arsenijevic, Aleksandar; Stojanovic, Bojan; Strazic Geljic, Ivana; Arsenijevic, Nebojsa; Jonjic, Stipan; Lukic, Miodrag L.; Milovanovic, Marija
Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection // Frontiers in Microbiology, 10 (2019), 185, 13 doi:10.3389/fmicb.2019.00185 (međunarodna recenzija, članak, znanstveni)
Stojanovic, B., Milovanovic, J., Arsenijevic, A., Stojanovic, B., Strazic Geljic, I., Arsenijevic, N., Jonjic, S., Lukic, M. & Milovanovic, M. (2019) Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. Frontiers in Microbiology, 10, 185, 13 doi:10.3389/fmicb.2019.00185.
@article{article, author = {Stojanovic, Bojana and Milovanovic, Jelena and Arsenijevic, Aleksandar and Stojanovic, Bojan and Strazic Geljic, Ivana and Arsenijevic, Nebojsa and Jonjic, Stipan and Lukic, Miodrag L. and Milovanovic, Marija}, year = {2019}, pages = {13}, DOI = {10.3389/fmicb.2019.00185}, chapter = {185}, keywords = {galectin-3, hepatitis, murine cytomegalovirus infection, TNF-α, hepatocyte death}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2019.00185}, volume = {10}, issn = {1664-302X}, title = {Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection}, keyword = {galectin-3, hepatitis, murine cytomegalovirus infection, TNF-α, hepatocyte death}, chapternumber = {185} }
@article{article, author = {Stojanovic, Bojana and Milovanovic, Jelena and Arsenijevic, Aleksandar and Stojanovic, Bojan and Strazic Geljic, Ivana and Arsenijevic, Nebojsa and Jonjic, Stipan and Lukic, Miodrag L. and Milovanovic, Marija}, year = {2019}, pages = {13}, DOI = {10.3389/fmicb.2019.00185}, chapter = {185}, keywords = {galectin-3, hepatitis, murine cytomegalovirus infection, TNF-α, hepatocyte death}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2019.00185}, volume = {10}, issn = {1664-302X}, title = {Galectin-3 Deficiency Facilitates TNF-α- Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection}, keyword = {galectin-3, hepatitis, murine cytomegalovirus infection, TNF-α, hepatocyte death}, chapternumber = {185} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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