Naslov
Conformation and supramolecular interactions in O-alkylated quinoline and ferrocene conjugates

Autori
Cetina, Mario ; Maračić, Silvija ; Lapić, Jasmina ; Djaković, Senka ; Raić Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Twenty-seventh Slovenian-Croatian Crystallographic Meeting / Počkaj, Marta ; Pevec, Andrej - Ljubljana : Fakulteta za kemijo in kemijsko tehnologijo Univerze v Ljubljani, 2019, 60-60

Skup
27th Slovenian-Croatian Crystallographic Meeting (SCCM 2019)

Mjesto i datum
Rogaška Slatina, Slovenija, 19.06.2019. - 23.06.2019

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
ferrocene skeleton, quinoline ring, conformation, supramolecular assembling

Sažetak
Ferrocenes conjugated with biologically active heterocycles have been found to exhibit promising cytostatic effects, such as, carbohydrate ferrocene conjugates with amide or triazole linker were effective on some hormone‐dependent and hormone-independent cancer cells lines [1]. Besides, quinoline derivatives containing additional aromatic rings have been reported to possess potent anticancer activities [2]. In this contribution, we present supramolecular structures and conformation of three O-alkylated quinoline and ferrocene conjugates (Fig. 1). Cyclopentadienyl rings in 2 and 3 deviate only slightly from an eclipsed conformation, while in 1 it is almost halfway between eclipsed and staggered. In supramolecular structures dominate dimer motif formed by C-H···N or/and C-H···F hydrogen bonds. Their combination forms chain of rings, like in 2 (Fig. 2), while the C-H···Pi or/and Pi···Pi interactions extend this motif into three-dimensional or two-dimensional network. References: [1] Deepthi, S.B., Trivedi, R., Giribabu, L., Sujitha, P. & Kumar, C.G. (2013) Dalton Trans. 42, 1180-1190. [2] de Freitas, L.B., Borgati, T.F., de Freitas, R.P., Ruiz, A.L.T.G., Marchetti, G.M., de Carvalho, J.E., da Cunha, E.F.F., Ramalho, T.C. & Alves, R.B. (2014) Eur. J. Med. Chem. 84, 595-604.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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