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Pregled bibliografske jedinice broj: 1007020

Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates


Rončević, Tomislav; Gajski, Goran; Ilić, Nada; Goić-Barišić, Ivana; Tonkić, Marija; Simunić, Juraj; Juretić, Davor
Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates // Book of Abstracts
Rouen, Francuska, 2016. str. 245-245 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1007020 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates

Autori
Rončević, Tomislav ; Gajski, Goran ; Ilić, Nada ; Goić-Barišić, Ivana ; Tonkić, Marija ; Simunić, Juraj ; Juretić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2016, 245-245

Skup
RegPep 2016

Mjesto i datum
Rouen, Francuska, 12.07.2016. - 14.07.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Antimicrobial peptides ; PGLa-H ; Clinical isolates ; Multidrug resistant ; Cytoxicity

Sažetak
Antimicrobial peptides (AMPs) are promising candidates for new classes of antibiotics but tend to display an inacceptable toxicity to human cells. A naturally produced C-terminal fragment of PGLa, named PGLa-H, was reported to have a very low haemolytic activity with a moderate antibacterial activity. We designed of sequential tandem repeat of PGLa-H and its analogue with glycine substitution at key position. DiPGLa-H and its analogue showed markedly improved in vitro bacteriostatic and bactericidal activity against laboratory strains and multidrug resistant clinical isolates of both Gram-negative and Gram-positive pathogens. At the same time they were non-toxic for circulating human blood cells as assessed by geno/cytotoxicity and haemolysis assays. An analogue with a single glycine substitution showed a slightly better antibacterial activity and somewhat reduced cytotoxicity. In the future these peptides may serve as useful lead compounds for developing non-toxic anti-infective agents against multi-resistant pathogens, especially for topical uses.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-8481 - Biofizikalni dizajn antimikrobnih peptida i inovativni molekularni deskriptori (BioAmpMode) (Vukičević, Damir) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
KBC Split,
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split


Citiraj ovu publikaciju:

Rončević, Tomislav; Gajski, Goran; Ilić, Nada; Goić-Barišić, Ivana; Tonkić, Marija; Simunić, Juraj; Juretić, Davor
Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates // Book of Abstracts
Rouen, Francuska, 2016. str. 245-245 (poster, međunarodna recenzija, sažetak, znanstveni)
Rončević, T., Gajski, G., Ilić, N., Goić-Barišić, I., Tonkić, M., Simunić, J. & Juretić, D. (2016) Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates. U: Book of Abstracts.
@article{article, author = {Ron\v{c}evi\'{c}, Tomislav and Gajski, Goran and Ili\'{c}, Nada and Goi\'{c}-Bari\v{s}i\'{c}, Ivana and Tonki\'{c}, Marija and Simuni\'{c}, Juraj and Jureti\'{c}, Davor}, year = {2016}, pages = {245-245}, keywords = {Antimicrobial peptides, PGLa-H, Clinical isolates, Multidrug resistant, Cytoxicity}, title = {Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates}, keyword = {Antimicrobial peptides, PGLa-H, Clinical isolates, Multidrug resistant, Cytoxicity}, publisherplace = {Rouen, Francuska} }
@article{article, author = {Ron\v{c}evi\'{c}, Tomislav and Gajski, Goran and Ili\'{c}, Nada and Goi\'{c}-Bari\v{s}i\'{c}, Ivana and Tonki\'{c}, Marija and Simuni\'{c}, Juraj and Jureti\'{c}, Davor}, year = {2016}, pages = {245-245}, keywords = {Antimicrobial peptides, PGLa-H, Clinical isolates, Multidrug resistant, Cytoxicity}, title = {Design of PGLa-H tandem-repeat peptides with activity and selectivity testing against clinical bacterial isolates}, keyword = {Antimicrobial peptides, PGLa-H, Clinical isolates, Multidrug resistant, Cytoxicity}, publisherplace = {Rouen, Francuska} }




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