Pregled bibliografske jedinice broj: 1006408
Design and Synthesis of Immunostimulating Mannosylated Muropeptide Analogs Containing 2-Aminoadamantane-2- carboxylic Acid
Design and Synthesis of Immunostimulating Mannosylated Muropeptide Analogs Containing 2-Aminoadamantane-2- carboxylic Acid // 2nd Molecules Medicinal Chemistry Symposium: Facing Novel Challenges in Drug Discovery
Barcelona, Španjolska, 2019. str. 196-196 (poster, međunarodna recenzija, sažetak, ostalo)
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Naslov
Design and Synthesis of Immunostimulating Mannosylated Muropeptide Analogs Containing 2-Aminoadamantane-2- carboxylic Acid
Autori
Ribić, Rosana ; Paurević, Marija ; Tomić, Srđanka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
2nd Molecules Medicinal Chemistry Symposium: Facing Novel Challenges in Drug Discovery
/ - , 2019, 196-196
Skup
2nd Molecules Medicinal Chemistry Symposium
Mjesto i datum
Barcelona, Španjolska, 15.05.2019. - 17.05.2019
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
adamantane, desmuramyl peptides, mannose, immunostimulating activity
Sažetak
Peptidoglycan fragments of well defined structures, the best known of which are muramyl peptides, have been extensively studied as possible adjuvants for human and animal vaccines. Muramyl dipeptide (MDP, N-acetylmuramyl-L-alanyl-D-isoglutamine) is known as the smallest synthetic adjuvant molecule capable of replacing whole Mycobacteria in Freund’s adjuvant.1 Mannose receptors (MR), present on immunocompetent cells (such as macrophages and dendritic cells) are considered to be pattern- recognition receptors biding compounds with mannose, N-acetylglucosamine or fucose as their essential parts. Therefore, they are responsible for the binding, among others, of mannosylated antigens or relevant biologically active molecules containing mannose, thus affecting the immune reactions.2 Up to now our research in the field of potential adjuvants was directed towards desmuramyl peptides which contain adamantylglycine and mannosylated adamantylglycine moieties bound to the essential part of MDP, L-Ala-D-isoGln.3 Here we present synthesis and biological evaluation of novel mannosylated desmuramyl peptides containing glycolyl linker. Investigation of their immunostimulating activity was conducted in vivo in mouse model using ovalbumin as an antigen. Synthesized glycopeptides showed improved immunological activity than previously described mannosylated desmuramyl peptides with (R)- hydroxyisobutyl linker.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-7899 - Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikonjugata (PEPTGLYCOSAR) (Tomić-Pisarović, Srđanka, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Sveučilište J. J. Strossmayera u Osijeku,
Sveučilište Sjever, Koprivnica