Naslov
Structural basis for lipid interactions with glutathione peroxidase 4

Autori
Jednačak, Tomislav ; Bourgeois, Benjamin ; Madl, Tobias

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Adriatic NMR Conference 2019 : Book of abstracts / Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb, 2019, 35-35

ISBN
978-953-6076-56-7

Skup
Adriatic NMR 2019

Mjesto i datum
Mali Ston, Hrvatska, 06.06.2019. - 09.06.2019

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
lipid binding ; glutathione peroxidase 4 ; NMR spectroscopy ; reactive oxygen species

Sažetak
Biomolecular interactions with high specificity and a significant degree of affinity play vital roles in all cellular processes such as gene regulation, protein synthesis, molecular organisation and recognition events. Determining the three-dimensional structure of macromolecules, ligands and their complexes is essential for obtaining a deeper insight into molecular mechanisms and dynamics involved in these interactions. The main goal of this research is to study the underlying mechanisms of recognition and degradation of reactive oxygen species in biological systems. It is focused on structural characterisation of the interactions between an enzyme glutathione peroxidase 4 and its lipid substrates by NMR spectroscopy in order to clarify the role this enzyme plays in various biological processes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA