Naslov
Epidemiology of invasive bacterial disease in children before and after the introduction of vaccination against Haemophilus influenzae type b

Autori
Didović, Diana ; Papić, Neven ; Vrdoljak, Maja ; Butić, Iva ; Čeljuska Tošev, Elvira ; Knezović, Ivica ; Tešović, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, stručni

Izvornik
11th Croatian Congress of Clinical Microbiology and the 8th Croatian Congress for Infectious Diseases - Abstract Book / - , 2016

Skup
11th Croatian Congress of Clinical Microbiology and the 8th Croatian Congress for Infectious Diseases

Mjesto i datum
Poreč, Hrvatska, 20.09.2016. - 23.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
epidemiology ; invasive bacterial disease ; children ; vaccination ; haemophilus influenzae type b
(epidemiology ; invasive bacterial disease ; children ; vaccination ; haemophilus influenzae type)

Sažetak
Introduction: H. influenzae type b, S. pneumoniae and N. meningitidis were the leading causative agents of invasive bacterial diseases (IBD) among children of less than 5 years of age prior to the introduction of the H. influenzae type b conjugate vaccine. A significant decrease of invasive H. influenzae diseases (IHD) occured in nations that implemented routine Hib vaccination in their national immunization program (NIP). Aim: The goal of this study was to describe the frequency and characteristics of pediatric patients with IBD before and after implementation of routine Hib vaccination was implemented into the Croatian NIP. Subjects and methods: A retrospective analysis of administrative databases at University Hospital for Infectious Diseases “Dr. Fran Mihaljević”. Results: A total of 1112 pediatric patients’ (from 0 to 18 years of age) records with etiologically- proven IBD were analyzed. The patients were divided into three periods: first (reference) period prior to Hib vaccine introduction and two postvaccinal periods. During the second period, a statistically significant change in proportion occured for N. meningitidis (p<0, 05), S. agalactiae (p<0, 05) and H. influenzae (p<0, 0001). H. influenzae (p<0, 0001) maintained this trend during the third period as well. Additionally, a decrease in Hib meningitis cases was noted (p<0, 0001). Conclusion: The implementation of Hib vaccine in the Croatian NIP led to a significant decrease of IHD. S. pneumoniae and N. meningitidis are still the leading causative agents of IBD and thus the introduction of adequate pneumococcal and meningococal vaccine in Croatian NIP should be considered.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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