Naslov
Immune reaction of tumor-bearing mice to Propionibacterium acnes and the antitumor effect of the bacteria

Autori
Silobrčić, Vlatko ; Fredrickson, G. ; Sedlaček, Robert ; Suit, Herman D. ; Wolberg, G.

Izvornik
Cancer immunology and immunotherapy (0340-7004) 14 (1982), 1; 10-12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immune reaction ; viable cell ; cancer research ; acne ; antitumor effect

Sažetak
The relationship between immunological reaction to Propionibacterium acnes (PA) and the antitumor effect of the injected bacterium was investigated. The aim was to determine whether the strength of the immune reaction to the bacterium can be used to predict its antitumor effectiveness. C3Hf/Sed mice received SC injections (right thigh) of viable cells of a methylcholanthrene-induced fibrosarcoma. When the tumor grew to 5 mm, the hosts received 350 μg PA IV as the antitumor treatment. Cellular immunity (footpad test) to PA was assayed in one group of these mice 14 days later, and in the other anti-PA agglutinins were determined 28 days later. The PA injection cured 22 of 58 mice in the first, and 20 of 46 mice in the second group. Footpad reaction and agglutinin titers to PA in cured mice were not statistically different from those in mice eventually killed by the tumor. Therefore, the strength of the immune reaction to PA in tumor-bearing mice could not be used to predict the antitumor effectiveness of the bacterium.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je na hrvatskom jeziku, pod naslovom "Imunoreakcija miševa na propionibacterium acnes i antitumorski učinak bakterija" prezentiran na skupu 7. Jugoslavenski simpozij imunologa, održanom 1982.g., Radenci, Slovenija ; objavljen u Knjizi sažetaka, str. 114.

POVEZANOST RADA