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Pregled bibliografske jedinice broj: 1003511

Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin

Kapić, Samra; Fajdetić, Andrea; Koštrun, Sanja; Čikoš, Ana; Paljetak, Hana Čipčić; Antolović, Roberto; Holmes, David J.; Alihodžić, Sulejman
Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin // Bioorganic & Medicinal Chemistry, 19 (2011), 23; 7270-7280 doi:10.1016/j.bmc.2011.07.011 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin

Autori
Kapić, Samra ; Fajdetić, Andrea ; Koštrun, Sanja ; Čikoš, Ana ; Paljetak, Hana Čipčić ; Antolović, Roberto ; Holmes, David J. ; Alihodžić, Sulejman

Izvornik
Bioorganic & Medicinal Chemistry (0968-0896) 19 (2011), 23; 7270-7280

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antimicrobial activity ; Macrolides ; Macrolones ; Quinolone ; Structure–activity relationship

Sažetak
A set of novel macrolones containing the flexible C8 basic linker and quinolone 3-(2′-hydroxyethyl)carboxamido group has been prepared and structurally characterized by NMR and IR spectroscopy, mass spectrometry and molecular modeling. The new compounds were evaluated in vitro against a panel of erythromycin-susceptible and erythromycin-resistant Gram-positive and Gram-negative bacterial strains. Compared to azithromycin, most of the compounds exhibited improved in vitro potency against the key respiratory pathogens.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Ustanove:
Fidelta d.o.o.

Profili:

Avatar Url Andrea Fajdetić (autor)

Avatar Url Ana Čikoš (autor)

Avatar Url Roberto Antolović (autor)

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Sanja Koštrun (autor)

Avatar Url Samra Kapić (autor)

Avatar Url Sulejman Alihodžić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Kapić, Samra; Fajdetić, Andrea; Koštrun, Sanja; Čikoš, Ana; Paljetak, Hana Čipčić; Antolović, Roberto; Holmes, David J.; Alihodžić, Sulejman
Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin // Bioorganic & Medicinal Chemistry, 19 (2011), 23; 7270-7280 doi:10.1016/j.bmc.2011.07.011 (međunarodna recenzija, članak, znanstveni)
Kapić, S., Fajdetić, A., Koštrun, S., Čikoš, A., Paljetak, H., Antolović, R., Holmes, D. & Alihodžić, S. (2011) Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin. Bioorganic & Medicinal Chemistry, 19 (23), 7270-7280 doi:10.1016/j.bmc.2011.07.011.
@article{article, author = {Kapi\'{c}, Samra and Fajdeti\'{c}, Andrea and Ko\v{s}trun, Sanja and \v{C}iko\v{s}, Ana and Paljetak, Hana \v{C}ip\v{c}i\'{c} and Antolovi\'{c}, Roberto and Holmes, David J. and Alihod\v{z}i\'{c}, Sulejman}, year = {2011}, pages = {7270-7280}, DOI = {10.1016/j.bmc.2011.07.011}, keywords = {Antimicrobial activity, Macrolides, Macrolones, Quinolone, Structure–activity relationship}, journal = {Bioorganic and Medicinal Chemistry}, doi = {10.1016/j.bmc.2011.07.011}, volume = {19}, number = {23}, issn = {0968-0896}, title = {Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin}, keyword = {Antimicrobial activity, Macrolides, Macrolones, Quinolone, Structure–activity relationship} }
@article{article, author = {Kapi\'{c}, Samra and Fajdeti\'{c}, Andrea and Ko\v{s}trun, Sanja and \v{C}iko\v{s}, Ana and Paljetak, Hana \v{C}ip\v{c}i\'{c} and Antolovi\'{c}, Roberto and Holmes, David J. and Alihod\v{z}i\'{c}, Sulejman}, year = {2011}, pages = {7270-7280}, DOI = {10.1016/j.bmc.2011.07.011}, keywords = {Antimicrobial activity, Macrolides, Macrolones, Quinolone, Structure–activity relationship}, journal = {Bioorganic and Medicinal Chemistry}, doi = {10.1016/j.bmc.2011.07.011}, volume = {19}, number = {23}, issn = {0968-0896}, title = {Synthesis and activity of new macrolones: Conjugates between 6(7)-(2′-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2′-hydroxyethyl) amides and 4″-propenoyl-azithromycin}, keyword = {Antimicrobial activity, Macrolides, Macrolones, Quinolone, Structure–activity relationship} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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