Pregled bibliografske jedinice broj: 1003056
A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system
A ‘pathogenic needle’ in a ‘commensal haystack’: Genetic virulence signatures of Corynebacterium glucuronolyticum that may drive its infectious propensity for the male urogenital system // Medical hypotheses, 126 (2019), 38-41 doi:10.1016/j.mehy.2019.03.011 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1003056 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A ‘pathogenic needle’ in a ‘commensal haystack’:
Genetic virulence signatures of Corynebacterium
glucuronolyticum that may drive its infectious
propensity for the male urogenital system
Autori
Meštrović, Tomislav ; Wilson, Jonas ; Ljubin-Sternak, Sunčanica ; Sviben, Mario ; Bedenić, Branka ; Barać, Aleksandra ; Neuberg, Marijana ; Drenjančević, Domagoj ; Ribić, Rosana ; Kozina, Goran
Izvornik
Medical hypotheses (0306-9877) 126
(2019);
38-41
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Corynebacterium glucuronolyticum ; pathogenesis ; urogenital infections
Sažetak
The predominance of the genus Corynebacterium in the healthy male urogenital system contributes to the resident microbiome of not only the distal urethra, but potentially the proximal urethra and urinary bladder as well. However, for certain species in this genus, pathogenic potential was described, and the salient representative is Corynebacterium glucuronolyticum (C. glucuronolyticum) implicated in cases of urethritis and prostatitis in men. Nonetheless, some still question whether C. glucuronolyticum can actually be considered pathogenic or rather just a commensal species fortuitously isolated in patients with urogenital symptoms and/or syndromes. Although pathogen/commensal dichotomy is not always clear-cut, we hypothesize that specific genetic markers may expose C. glucuronolyticum as a convincingly pathogenic Corynebacterium. More specifically, characteristic pathogenic gene constellation inherent to this species (most notably the presence of specific sortase/SpaA-type pili gene clusters, but also the augmentative role of type VII secretion system) may significantly facilitate host tissue adhesion, with subsequent suppression/evasion of the immune response and acquisition of vitally important nutrients. Consequently, these genetic markers differentiate C. glucuronolyticum from its commensal counterparts, and give this species a pathogenic facet, which can be even further influenced by the Allee effect. In this paper we also propose a specific methodological approach on how to analyze C. glucuronolyticum epithelial colonization capacity and explore inceptive host cell-pathogen interactions that manipulate host environment and immune responses. This entails moving from approaches based primarily on overall homology of primary sequences towards specific structure-function studies to precisely evaluate all stakeholders involved in pili assemblage, cell adhesion and the expression of other virulence traits. In the era of high precision medicine, the hypothesized roles of C. glucuronolyticum adhesion systems in both virulence and nutrient acquisition may also reveal promising targets for future drug developments.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Hrvatski zavod za javno zdravstvo,
Medicinski fakultet, Zagreb,
Nastavni zavod za javno zdravstvo "Dr. Andrija Štampar",
Klinički bolnički centar Osijek,
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek,
Sveučilište Sjever, Koprivnica
Profili:
Tomislav Meštrović
(autor)
Rosana Ribić
(autor)
Domagoj Drenjančević
(autor)
Mario Sviben
(autor)
Goran Kozina
(autor)
Marijana Neuberg
(autor)
Branka Bedenić
(autor)
Sunčanica Ljubin Sternak
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE