Naslov
Correlation between HLA-A and HLA-B gene polymorphism and the risk of uveitis in East Croatia

Autori
Suver Stević, Mirjana ; Ferenac Kiš, Marina ; Bugarin, Anđelka ; Krizmanić, Kristina ; Nemet- Gužvić, Renata ; Tokić, Stana ; Glavaš-Obrovac, Ljubica ; Samardžija, Marina ; Matić, Suzana ; Marczi, Saška

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Special Issue: Abstracts for the 33rd European Immunogenetics and Histocompatibility Conference / Marsh, Steven G. E - : John Wiley & Sons, 2019, 359-360

Skup
33rd European Immunogenetics and Histocompatibility Conference

Mjesto i datum
Lisabon, Portugal, 08.05.2019. - 11.05.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA, uveitis

Sažetak
Uveitis is inflammation of the middle layer of the eye which cause damage of vital eye tissue and can lead to permanent vision loss. This complex disease may be localized to the eye or may be associated with systemic diseases. Several studies reported polygenic correlation to uveitis phenotypes, with emphasis on the association of HLA with the development and clinical course of uveitis. The goal of this study was to investigate the HLA-A and HLA-B gene polymorphisms that might predispose to uveitis in East Croatia. The group of 38 patients (20 males, 18 females) aged 8-65 years (mean 39.1 ± 15.6 years) was HLA typed using a PCR-SSP method at low resolution level in the period of 2007-2018. HLA-A and -B gene frequencies in group of patients were calculated in regard to control group of healthy unrelated bone marrow donors from Croatia. Comparison was conducted using Fisher’s (two-tailed) exact test. In a group of patients, 11 different variants of HLA-A and 16 different variants of HLA-B gene were found. The most common were HLA-A*02 (33.78 %), -A*03 (14.86 %), -A*01 (12.16 %) and -A*24 (10.81 %) and HLA-B*44 (15.79 %), -B*27 (11.84 %), -B*35 (11.84 %), -B*51 (11.84 %) and -B*08 (9.21 %). The HLA-B*27 (GF 11.84 vs 6.21 ; OR 2.03) and HLA-B*44 (GF 15.97 vs 9.3 ; OR 1.83) showed positive association with uveitis with statistical significance close to 0.05 (p=0.054 and p=0.071, respectively). In contrast, HLA- A*68 (GF 0.00 vs 4.61 ; OR 0.14 ; p=0.049) indicated a potential protective role for uveitis development in population of East Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA