Pregled bibliografske jedinice broj: 1002558
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans // Immunobiology, 224 (2019), 1; 110-115 doi:10.1016/j.imbio.2018.10.002 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1002558 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans
Autori
Russell, Alyce C. ; Kepka, Agnieszka ; Trbojević-Akmačić, Irena ; Ugrina, Ivo ; Song, Manshu ; Hui, Jennie ; Hunter, Michael ; Laws, Simon M. ; Lauc, Gordan ; Wang, Wei
Izvornik
Immunobiology (0171-2985) 224
(2019), 1;
110-115
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Body mass index ; Central adiposity ; Glycosylation ; Immunoglobulin G ; Pro-inflammation
Sažetak
Background Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans. Aim We aimed to determine the association between increased body fat and the immunoglobulin G glycosylation features, comparing body mass index to other measures of body fat distribution. Methods We investigated a sample of 637 community-based 45–69 year olds, with mixed phenotypes, residing in Busselton, Western Australia. Body mass index and the waist-to-hip and waist-to-height ratios were calculated using anthropometry, while dual- energy x-ray absorptiometry was performed to gain an accurate measure of total and area specific body fat. Serum immunoglobulin GN- glycans were analysed by ultra-performance liquid chromatography. Results Twenty-two N- glycan peaks were found to be associated with at least one of the fat measures. While the previous association of body mass index to agalactosylated immunoglobulin G was replicated, measures of central adiposity explained the most variation in the immunoglobulin G glycome. Conclusion Central adiposity is associated with an increased pro- inflammatory fraction of immunoglobulin G, suggesting that the android/gynoid ratio or waist-to-height ratio instead be considered when controlling for adiposity in immunoglobulin G glycome biomarker studies.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
EK-FP7-305280 - Methods for Integrated analysis of Multiple Omics datasets (MIMOMICS) (Lauc, Gordan, EK - FP7-HEALTH-2012-INNOVATION-1) ( CroRIS)
EK-FP7-324400 - Methods for high-throughput glycoproteomic analysis (HTP-GLYCOMET) (Jonjić, Stipan, EK - FP7-PEOPLE-2012-IAPP) ( CroRIS)
EK-FP7-602736 - Multi-dimensional omics approach to stratification of patients with low back pain (PAIN-OMICS) (Primorac, Dragan; Lauc, Gordan, EK - FP7-HEALTH-2013-INNOVATION-1) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split,
Sveučilište u Splitu,
GENOS d.o.o.
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
