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Pregled bibliografske jedinice broj: 1002553

Plasma N-glycans in colorectal cancer risk

Doherty, Margaret; Theodoratou, Evropi; Walsh, Ian; Adamczyk, Barbara; Stöckmann, Henning; Agakov, Felix; Timofeeva, Maria; Trbojević-Akmačić, Irena; Vučković, Frano; Duffy, Fergal et al.
Plasma N-glycans in colorectal cancer risk // Scientific Reports, 8 (2018), 1; 8655, 12 doi:10.1038/s41598-018-26805-7 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1002553 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Plasma N-glycans in colorectal cancer risk

Autori
Doherty, Margaret ; Theodoratou, Evropi ; Walsh, Ian ; Adamczyk, Barbara ; Stöckmann, Henning ; Agakov, Felix ; Timofeeva, Maria ; Trbojević-Akmačić, Irena ; Vučković, Frano ; Duffy, Fergal ; McManus, Ciara A. ; Farrington, Susan M. ; Dunlop, Malcolm G. ; Perola, Markus ; Lauc, Gordan ; Campbell, Harry ; Rudd, Pauline M.

Izvornik
Scientific Reports (2045-2322) 8 (2018), 1; 8655, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glycosylation, crc

Sažetak
Aberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasma N-glycosylation between colorectal cancer (CRC) cases and controls in one of the largest cohorts of its kind. A set of 633 CRC patients and 478 age and gender matched controls was analysed. Additionally, patients were stratified into four CRC stages. Moreover, N-glycan analysis was carried out in plasma of 40 patients collected prior to the initial diagnosis of CRC. Statistically significant differences were observed in the plasma N-glycome at all stages of CRC, this included a highly significant decrease in relation to the core fucosylated bi-antennary glycans F(6)A2G2 and F(6)A2G2S(6)1 (P < 0.0009). Stage 1 showed a unique biomarker signature compared to stages 2, 3 and 4. There were indications that at risk groups could be identified from the glycome (retrospective AUC = 0.77 and prospective AUC = 0.65). N-glycome biomarkers related to the pathogenic progress of the disease would be a considerable asset in a clinical setting and it could enable novel therapeutics to be developed to target the disease in patients at risk of progression.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
EK-FP7-259869 - Tools for the Detection of Novel Glyco-biomarkers (GLYCOBIOM) (Lauc, Gordan, EK - FP7-HEALTH-2010-two-stage) ( CroRIS)
EK-FP7-278535 - Methods for high-throughput (HTP) analysis of protein glycosylation (HIGHGLYCAN) (Lauc, Gordan, EK - FP7-HEALTH-2011-two-stage) ( CroRIS)
EK-FP7-305280 - Methods for Integrated analysis of Multiple Omics datasets (MIMOMICS) (Lauc, Gordan, EK - FP7-HEALTH-2012-INNOVATION-1) ( CroRIS)
EK-FP7-324400 - Methods for high-throughput glycoproteomic analysis (HTP-GLYCOMET) (Jonjić, Stipan, EK - FP7-PEOPLE-2012-IAPP) ( CroRIS)
EK-FP7-305479 - Diagnostic and prognostic biomarkers for inflammatory bowel disease (IBD-BIOM) (Zoldoš, Vlatka, EK - FP7-HEALTH-2012-INNOVATION-1) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Profili:

Avatar Url Gordan Lauc (autor)

Avatar Url IRENA TRBOJEVIĆ AKMAČIĆ (autor)

Avatar Url Frano Vučković (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.nature.com

Citiraj ovu publikaciju:

Doherty, Margaret; Theodoratou, Evropi; Walsh, Ian; Adamczyk, Barbara; Stöckmann, Henning; Agakov, Felix; Timofeeva, Maria; Trbojević-Akmačić, Irena; Vučković, Frano; Duffy, Fergal et al.
Plasma N-glycans in colorectal cancer risk // Scientific Reports, 8 (2018), 1; 8655, 12 doi:10.1038/s41598-018-26805-7 (međunarodna recenzija, članak, znanstveni)
Doherty, M., Theodoratou, E., Walsh, I., Adamczyk, B., Stöckmann, H., Agakov, F., Timofeeva, M., Trbojević-Akmačić, I., Vučković, F. & Duffy, F. (2018) Plasma N-glycans in colorectal cancer risk. Scientific Reports, 8 (1), 8655, 12 doi:10.1038/s41598-018-26805-7.
@article{article, author = {Doherty, Margaret and Theodoratou, Evropi and Walsh, Ian and Adamczyk, Barbara and St\"{o}ckmann, Henning and Agakov, Felix and Timofeeva, Maria and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Vu\v{c}kovi\'{c}, Frano and Duffy, Fergal and McManus, Ciara A. and Farrington, Susan M. and Dunlop, Malcolm G. and Perola, Markus and Lauc, Gordan and Campbell, Harry and Rudd, Pauline M.}, year = {2018}, pages = {12}, DOI = {10.1038/s41598-018-26805-7}, chapter = {8655}, keywords = {glycosylation, crc}, journal = {Scientific Reports}, doi = {10.1038/s41598-018-26805-7}, volume = {8}, number = {1}, issn = {2045-2322}, title = {Plasma N-glycans in colorectal cancer risk}, keyword = {glycosylation, crc}, chapternumber = {8655} }
@article{article, author = {Doherty, Margaret and Theodoratou, Evropi and Walsh, Ian and Adamczyk, Barbara and St\"{o}ckmann, Henning and Agakov, Felix and Timofeeva, Maria and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Vu\v{c}kovi\'{c}, Frano and Duffy, Fergal and McManus, Ciara A. and Farrington, Susan M. and Dunlop, Malcolm G. and Perola, Markus and Lauc, Gordan and Campbell, Harry and Rudd, Pauline M.}, year = {2018}, pages = {12}, DOI = {10.1038/s41598-018-26805-7}, chapter = {8655}, keywords = {glycosylation, crc}, journal = {Scientific Reports}, doi = {10.1038/s41598-018-26805-7}, volume = {8}, number = {1}, issn = {2045-2322}, title = {Plasma N-glycans in colorectal cancer risk}, keyword = {glycosylation, crc}, chapternumber = {8655} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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