Naslov
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm?

Autori
Stemberger Marić, Lorna ; Židovec Lepej, Snježana ; Gorenec, Lana ; Grgić, Ivana ; Trkulja, Vladimir ; Đaković Rode, Oktavija ; Roglić, Srđan ; Grmoja, Tonči ; Barišić, Nina ; Tešović, Goran

Izvornik
Neurological sciences (1590-1874) 39 (2018), 3; 471-479

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CXCL10 ; CXCL11 ; CXCL13 ; Acute disseminated encephalomyelitis ; Non-polio enterovirus aseptic meningitis ; Neuroborreliosis

Sažetak
We investigated potential diagnostic usefulness of serum and cerebrospinal fluid (CSF) concentrations of chemokines CXCL10, CXCL11, and CXCL13 in pediatric patients with acute disseminated encephalomyelitis (ADEM) (n = 23), non-polio enterovirus aseptic meningitis (NPEV AM) (n = 20), and neuroborreliosis (NB) (n = 21) and children with acute infectious diseases with neurological symptoms but with excluded neuroinfection/neuroinflammation (controls, n = 20). CSF levels of CXCL10 and CXCL11 were higher in patients with NPEV AM than those in other children, and CXCL10 levels showed a high discriminative potential (area under the receiver operating characteristic curve, ROC, 0.982) with high specificity and sensitivity (both 95%). CSF levels of CXCL13 were higher in NB patients than those in other children ; however, discriminative potential (area under ROC curve 0.814) and diagnostic properties were moderate (sensitivity 67%, specificity 97%). Data suggest usefulness of chemokine quantification as a diagnostic aid in children with suspected ADEM, NPEV AM, or NB.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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