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Pregled bibliografske jedinice broj: 999924

PD-L1 expression in various NSCLC cytology samples prepared as non-cell blocks


Šimić, Vesna; Vrabec Branica, Božica; Harabajsa, Suzana; Marušić, Ante; Badovinac, Sonja; Jakopović, Marko; Smojver-Ježek, Silvana
PD-L1 expression in various NSCLC cytology samples prepared as non-cell blocks // Toraks 2019
Zagreb, Hrvatska, 2019. str. 1-1 (poster, podatak o recenziji nije dostupan, sažetak, stručni)


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Naslov
PD-L1 expression in various NSCLC cytology samples prepared as non-cell blocks

Autori
Šimić, Vesna ; Vrabec Branica, Božica ; Harabajsa, Suzana ; Marušić, Ante ; Badovinac, Sonja ; Jakopović, Marko ; Smojver-Ježek, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Skup
Toraks 2019

Mjesto i datum
Zagreb, Hrvatska, 10. - 13. 04. 2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
PD-L1, NSCLC, Cytology

Sažetak
To compare PD-L1 expression between cytology samples obtained with bronchoscopy (bronchial washing/brushing ; BW/BB and transbronchial fine needle aspirations ; TBFNA) and other cytology samples such as pleural effusion, FNA of peripheral lymph nodes, FNA of skin nodules and transthoracic FNA/biopsy ; all prepared as non-cell block cytology. Materials and methods: We compared archive records of the result of PD-L1 expression in relation to specimen type (bronchoscopic and non-bronchoscopic samples) prepared as smears at our institution over a one year period. Air dried cytology smears and cytospins of NSCLC were stained with Anti-PD-L1, Clone 22C3, Dako on Autostainer. PD-L1 protein expression was scored by using Tumor Proportion Score (TPS) with positive cut-off of ≥1%. The slides were routinely examined and scored by two cytologists. Result: Out of 393 cytological smears that underwent PD-L1 scoring we have compared 341 smears. There were 216 samples of materials collected during bronchoscopy and 125 of various other samples ; 37 were obtained by FNA of peripheral lymph nodes, 28 by FNA of skin nodules, 28 by transthoracic FNA/biopsy and 32 pleural effusion. PD-L1 stained negative in total of 179/341 (52, 49%) samples. PD-L1 stained positive in total of 162/341(47, 50%) samples of which 105 were obtained with bronchoscopy and 57 of samples collected with other methods. Among of total PD-L1 positive smears, 72 were PD-L1 positive ≥ 50% ; 45/105 (42, 8%) were bronchoscopical samples and 27/57(47, 3%) other samples. Comparison in PD-L1 expression between two groups of samples showed no statistical significant difference among groups (X2 test, df 1, p=0, 591). Comparison between two groups of PD-L1 positive ≥ 50% showed no statistical significant difference among samples groups (X2 test, df 1, p=0, 581). Conclusion: There were no statistical significant differences in PD-L1 protein expression between samples collected during bronchoscopy and non-bronchoscopic samples prepared as non-cell block cytology. PD-L1 expression was independent of cytology sample type in our study.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Šimić, Vesna; Vrabec Branica, Božica; Harabajsa, Suzana; Marušić, Ante; Badovinac, Sonja; Jakopović, Marko; Smojver-Ježek, Silvana
PD-L1 expression in various NSCLC cytology samples prepared as non-cell blocks // Toraks 2019
Zagreb, Hrvatska, 2019. str. 1-1 (poster, podatak o recenziji nije dostupan, sažetak, stručni)
Šimić, V., Vrabec Branica, B., Harabajsa, S., Marušić, A., Badovinac, S., Jakopović, M. & Smojver-Ježek, S. (2019) PD-L1 expression in various NSCLC cytology samples prepared as non-cell blocks. U: Toraks 2019.
@article{article, year = {2019}, pages = {1-1}, keywords = {PD-L1, NSCLC, Cytology}, title = {PD-L1 expression in various NSCLC cytology samples prepared as non-cell blocks}, keyword = {PD-L1, NSCLC, Cytology}, publisherplace = {Zagreb, Hrvatska} }