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Pregled bibliografske jedinice broj: 999460

Fuzzy Interactions Form and Shape the Histone Transport Complex


Ivić, Nives; Potočnjak, Mia; Solis-Mezarino, Victor; Herzog, Franz; Bilokapić, Silvija; Halić, Mario
Fuzzy Interactions Form and Shape the Histone Transport Complex // Molecular cell, 73 (2019), 6; 1191-1203 doi:10.1016/j.molcel.2019.01.032 (međunarodna recenzija, članak, znanstveni)


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Naslov
Fuzzy Interactions Form and Shape the Histone Transport Complex

Autori
Ivić, Nives ; Potočnjak, Mia ; Solis-Mezarino, Victor ; Herzog, Franz ; Bilokapić, Silvija ; Halić, Mario

Izvornik
Molecular cell (1097-2765) 73 (2019), 6; 1191-1203

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nuclear import ; Histone H1 ; Imp7 ; Impβ ; Transport receptors ; Karyopherins ; Cryo-EM ; Disordered proteins ; IDP

Sažetak
Protein transport into the nucleus is mediated by transport receptors. Import of highly charged proteins, such as histone H1 and ribosomal proteins, requires a dimer of two transport receptors. In this study, we determined the cryo-EM structure of the Imp7:Impβ:H1.0 complex, showing that the two importins form a cradle that accommodates the linker histone. The H1.0 globular domain is bound to Impβ, whereas the acidic loops of Impβ and Imp7 chaperone the positively charged C-terminal tail. Although it remains disordered, the H1 tail serves as a zipper that closes and stabilizes the structure through transient non-specific interactions with importins. Moreover, we found that the GGxxF and FxFG motifs in the Imp7 C-terminal tail are essential for Imp7:Impβ dimerization and H1 import, resembling importin interaction with nucleoporins, which, in turn, promote complex disassembly. The architecture of many other complexes might be similarly defined by rapidly exchanging electrostatic interactions mediated by disordered regions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Silvija Bilokapić (autor)

Avatar Url Nives Ivić (autor)

Citiraj ovu publikaciju:

Ivić, Nives; Potočnjak, Mia; Solis-Mezarino, Victor; Herzog, Franz; Bilokapić, Silvija; Halić, Mario
Fuzzy Interactions Form and Shape the Histone Transport Complex // Molecular cell, 73 (2019), 6; 1191-1203 doi:10.1016/j.molcel.2019.01.032 (međunarodna recenzija, članak, znanstveni)
Ivić, N., Potočnjak, M., Solis-Mezarino, V., Herzog, F., Bilokapić, S. & Halić, M. (2019) Fuzzy Interactions Form and Shape the Histone Transport Complex. Molecular cell, 73 (6), 1191-1203 doi:10.1016/j.molcel.2019.01.032.
@article{article, year = {2019}, pages = {1191-1203}, DOI = {10.1016/j.molcel.2019.01.032}, keywords = {Nuclear import, Histone H1, Imp7, Impβ, Transport receptors, Karyopherins, Cryo-EM, Disordered proteins, IDP}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2019.01.032}, volume = {73}, number = {6}, issn = {1097-2765}, title = {Fuzzy Interactions Form and Shape the Histone Transport Complex}, keyword = {Nuclear import, Histone H1, Imp7, Impβ, Transport receptors, Karyopherins, Cryo-EM, Disordered proteins, IDP} }
@article{article, year = {2019}, pages = {1191-1203}, DOI = {10.1016/j.molcel.2019.01.032}, keywords = {Nuclear import, Histone H1, Imp7, Impβ, Transport receptors, Karyopherins, Cryo-EM, Disordered proteins, IDP}, journal = {Molecular cell}, doi = {10.1016/j.molcel.2019.01.032}, volume = {73}, number = {6}, issn = {1097-2765}, title = {Fuzzy Interactions Form and Shape the Histone Transport Complex}, keyword = {Nuclear import, Histone H1, Imp7, Impβ, Transport receptors, Karyopherins, Cryo-EM, Disordered proteins, IDP} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index


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