engleski

Study of the properties and cells growth on antibacterial electrospun polycaprolactone/cefuroxime scaffolds

Electrospun materials are good candidates for the design of tissue regeneration scaffolds as can simulate the natural surroundings of tissue cells. The study proposes electrospun polycaprolactone (PCL)/cefuroxime (CFU) scaffolds for human cells culture and investigates the influence of the antibiotic content on scaffolds morphology, thermal and mechanical properties. The increase in the CFU concentration resulted in fibers diameter and number of deformations reduction. It also influenced the reduction of scaffolds thermal enthalpies and improved scaffolds break strength. In regard to cells growth the scaffolds showed precedence in greater colonization of the HeLa cells. Finally these scaffolds showed compatibility with standard human cell lines, thus can be used for the repair of damaged tissues.

Electrospun ; scaffolds ; PCL ; Cefuroxime ; SEM ; DSC ; tensile behaviour ; HeLa ; Hep G2

Glavni autor: Budimir Mijović