engleski

Genetic Classification of Spitzoid Melanoma

In the 2018 WHO classification of skin tumours, a new entity, malignant Spitz tumor, is defined as melanoma that harbours one of the initiating alterations that are found in Spitz nevi. It is unclear how often spitzoid melanomas, which are defined solely by their histopathologic features, belong to this new genetically distinct category. We performed high coverage DNA sequencing of 480 cancer related genes in a cohort of spitzoid melanomas.

Malignant Spitz tumor ; Next-generation sequencing ; kinase fusions ; TERT promoter mutations

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