engleski

Calcium oxalate urolithiasis in children: urirary promoters/inhibitors and role of their ratios

Urinary excretion of oxalate, citrate, glycosaminoglycans and the ratios oxalate/citrate, oxalate/glycosaminoglycans, oxalate/(citrate × glycosaminoglycans), and citrate/glycosaminoglycans were examined in 83 children with idiopathic urolithiasis. Gene mutations causing primary hyperoxaluria and idiopathic hyperoxaluria HOGA 1 were excluded. Only the variable oxalate/(citrate × glycosaminoglycans) mmol/mol creatinine was able to distinguish between children with urolithiasis and healthy children. ROC analysis showed that the value of the ratio > 0.0782 is adequate for diagnostic purpose. Therefore, we consider that the ratio oxalate/(citrate × glycosaminoglycans) above 0.0782 indicates urolithiasis in children.

Urinary excretion of oxalate, citrate and glycosaminoglycans in children with urolithiasis

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