Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 998929

Innovative sprayable in situ gelling fluticasone suspension: Development and optimization of nasal deposition


Nižić, Laura; Ugrina, Ivo; Špoljarić, Drago; Saršon, Vesna; Safundžić Kučuk, Maša; Pepić, Ivan; Hafner, Anita
Innovative sprayable in situ gelling fluticasone suspension: Development and optimization of nasal deposition // International journal of pharmaceutics, 563 (2019), 445-456 doi:10.1016/j.ijpharm.2019.04.015 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 998929 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Innovative sprayable in situ gelling fluticasone suspension: Development and optimization of nasal deposition

Autori
Nižić, Laura ; Ugrina, Ivo ; Špoljarić, Drago ; Saršon, Vesna ; Safundžić Kučuk, Maša ; Pepić, Ivan ; Hafner, Anita

Izvornik
International journal of pharmaceutics (0378-5173) 563 (2019); 445-456

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Fluticasone ; Pectin ; Gellan gum ; Sodium hyaluronate ; In situ gelling ; Nasal deposition

Sažetak
The aim of this study was to develop an innovative in situ gelling suspension for effective nasal delivery of fluticasone. Pectin, gellan gum and sodium hyaluronate were used as gelling/thickening agents, and Tween 80 as a suspending agent. The influence of the formulation and/or administration parameters on formulation sprayability and nasal deposition was explored with an appropriate experimental design with the range for parameters in the design obtained from previous research and domain knowledge. All formulations exhibited appropriate sprayability and instant gelation upon mixing with simulated nasal fluid exhibiting weak gel properties convenient for nasal delivery. Targeted turbinate deposition depended on administration and formulation parameters, including their interactions. Decrease in the administration angle from horizontal plane, increase in inspiratory flow and presence of sodium hyaluronate significantly increased deposition in turbinate region. Parameters in interactions included concentration of polymers, surfactant and fluticasone, as well as administration angle. Selected formulations with high turbinate deposition exhibited significant increase in viscosity upon gelation, showing potential to prolong the drug retention at the nasal mucosa. The highest effect on the gel viscosity, strength and fluticasone release profile was observed for gellan gum, thus recognised as crucial parameter for the optimisation of overall therapeutic effect.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-UIP-2017-05-4592 - Optimiranje depozicije raspršenih in situ gelirajućih i praškastih terapijskih sustava u nosnoj šupljini (Anita Hafner, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split

Profili:

Avatar Url Anita Hafner (autor)

Avatar Url Ivan Pepić (autor)

Avatar Url Drago Špoljarić (autor)

Avatar Url Ivo Ugrina (autor)

Avatar Url Laura Nižić (autor)

Citiraj ovu publikaciju

Nižić, Laura; Ugrina, Ivo; Špoljarić, Drago; Saršon, Vesna; Safundžić Kučuk, Maša; Pepić, Ivan; Hafner, Anita
Innovative sprayable in situ gelling fluticasone suspension: Development and optimization of nasal deposition // International journal of pharmaceutics, 563 (2019), 445-456 doi:10.1016/j.ijpharm.2019.04.015 (međunarodna recenzija, članak, znanstveni)
Nižić, L., Ugrina, I., Špoljarić, D., Saršon, V., Safundžić Kučuk, M., Pepić, I. & Hafner, A. (2019) Innovative sprayable in situ gelling fluticasone suspension: Development and optimization of nasal deposition. International journal of pharmaceutics, 563, 445-456 doi:10.1016/j.ijpharm.2019.04.015.
@article{article, year = {2019}, pages = {445-456}, DOI = {10.1016/j.ijpharm.2019.04.015}, keywords = {Fluticasone, Pectin, Gellan gum, Sodium hyaluronate, In situ gelling, Nasal deposition}, journal = {International journal of pharmaceutics}, doi = {10.1016/j.ijpharm.2019.04.015}, volume = {563}, issn = {0378-5173}, title = {Innovative sprayable in situ gelling fluticasone suspension: Development and optimization of nasal deposition}, keyword = {Fluticasone, Pectin, Gellan gum, Sodium hyaluronate, In situ gelling, Nasal deposition} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati