engleski

Biocompatibility assessment of selenium nanoparticles as novel biocidal nanomaterial

Selenium nanoparticles represent promising candidates in nanomedicine due to their biocidal and atioxidant activity, biocompatibility and biodegradability. In this study different selenium nanoparticles were designed using polyacrylic acid (PAA), polyvinylpyrrolidone (PVP) and poly-L-lysine (PLL) as surface modifiers. Physio-chemical characterization was performed regarding particle size, size distribution and surface charge using dynamic light scattering. Visualization was carried out with transmission electron microscopy. Prior to in vitro testing, evaluation of SeNP stability in cell culture media was determined by means of agglomeration and dissolution behavior.

Nanoparticles ; selenium ; keratinocytes ; buccal cells ; oxidative stress

NanoPasS - Pharmacokinetic profiling of silver nanoparticles: the role of biological barriers