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Pregled bibliografske jedinice broj: 997820

Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells


Mioč, Marija; Marjanović, Marko; Guberović, Iva; Kralj, Marijeta
Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells // Libri oncologici Vol. XLVI
Zagreb, 2018. str. 63-63 (poster, podatak o recenziji nije dostupan, sažetak, ostalo)


CROSBI ID: 997820 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells

Autori
Mioč, Marija ; Marjanović, Marko ; Guberović, Iva ; Kralj, Marijeta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Libri oncologici Vol. XLVI / - Zagreb, 2018, 63-63

Skup
HDIR-5: Translating Science to Medicine - Targets and Therapeutics

Mjesto i datum
Zagreb, Hrvatska, 8-10.11.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
Multidrug resistance, ABC transporters, Crown ethers

Sažetak
Multidrug resistance (MDR) is a known characteristic of many cancers and is a major cause of failure of chemotherapy treatments. Various cellular pathways are responsible for this phenomenon, including overexpression of ATP binding cassette (ABC) transporters called ABCB1 (MDR1/P-glycoprotein) and ABCG2 (BCRP) by cancer cells, which makes this group of proteins a valuable target for cancer therapy by reversal of MDR. Salinomycin, naturally occurring potassium (K+) ionophore, was shown to inhibit P-gp transporter and to reverse MDR effectively. Salinomycin is a K+/H+ exchanger that can affect cation transport across different cellular membranes and thus impact on membranes’ bioenergetic performance, including mitochondrial membrane polarization and function. Based on the above-mentioned studies and anticancer activity of crown-ethers that act as K+ ionophores (previously published by our group), we showed that these compounds exhibit inhibitory effect towards ABC transporters, disrupt the potassium transport and modulate mitochondrial membrane transport. In this study, we showed the effect of adamantane-substituted monoaza- and diaza-18- crown-6 ether compounds on MDR reversal and their effect on mitochondrial membrane function, depending on their lipophilicity as well as on the chemical structure of the linker to adamantane moiety. Compounds that showed as the most potent P-gp and ABCG2 inhibitors were able to sensitize cancer cells to conventional chemotherapeutics paclitaxel and mitoxantrone, the substrates of P-gp and ABCG2 transporters, respectively. These data are promising and demonstrate a potential use of crown ethers in cancer therapy, by their ability to reverse MDR.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (MultiCaST) (Kralj, Marijeta, HRZZ - 2013-11) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marijeta Kralj (autor)

Avatar Url Marko Marjanović (autor)

Avatar Url Marija Mioč (autor)


Citiraj ovu publikaciju

Mioč, Marija; Marjanović, Marko; Guberović, Iva; Kralj, Marijeta
Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells // Libri oncologici Vol. XLVI
Zagreb, 2018. str. 63-63 (poster, podatak o recenziji nije dostupan, sažetak, ostalo)
Mioč, M., Marjanović, M., Guberović, I. & Kralj, M. (2018) Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells. U: Libri oncologici Vol. XLVI.
@article{article, year = {2018}, pages = {63-63}, keywords = {Multidrug resistance, ABC transporters, Crown ethers}, title = {Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells}, keyword = {Multidrug resistance, ABC transporters, Crown ethers}, publisherplace = {Zagreb, Hrvatska} }
@article{article, year = {2018}, pages = {63-63}, keywords = {Multidrug resistance, ABC transporters, Crown ethers}, title = {Proprietary crown ethers reverse multidrug resistance and affect mitochondrial function in cancer cells}, keyword = {Multidrug resistance, ABC transporters, Crown ethers}, publisherplace = {Zagreb, Hrvatska} }




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