engleski

Guided Bone Regeneration using biphasic calcium phosphate paste: study plan and preliminary histological findings

Introduction: Human bone has great potential for regeneration. Bone remodeling is balance of two processes: bone resorption by osteoclast and bone healing by osteoblast. The purpose of augmentation procedures in implant dentistry is to promote bone regeneration by using different biomaterials. Autogenous bone, allografts, xenografts and alloplastic materials in combination with resorbable or non-resorbable membranes are used in Guided Bone Regeneration (GBR), which is one of the most frequently used techniques in implant dentistry, with a predictable clinical outcome. In present study we want to assess and describe bone histology 6 months after GBR. Materials and methods: The study will include twenty healthy patients with at least one or two wall intrabony defects after tooth extraction. The intrabony defects are filled with biphasic calcium phosphate paste (Maxresorb inject, Botiss Dental GmbH) and covered with native collagen membrane (Jason membrane, Botiss Dental GmbH), to ensure the isolation of the bone defect against gingival connective tissue and epithelium. Six months after healing, simultaneously with dental implant placement, bone biopsies for histological analysis will be harvested. Following parameters will be determined: percentage of new bone formation, percentage of the residual biomaterial and percentage of the soft tissue. Preliminary results: This report presents preliminary histological findings of the osteoconductive properties of Maxresorb inject. The histological examation of the specimen showed new bone formation at the peripheral border of the bone defect. The granules of Maxresorb inject are incorporated into bone tissue and there are no histological signs of inflammation. Conclusion: In present study we evaluated the regenerated bone by descriptive histological examination. Maxresorb inject shows octeoconductive potential for bone regeneration. Further work is needed to complete histological, radiological and clinical evidences of osteoconductive properties of Maxresorb inject.

guided bone regeneration ; implant dentistry ; Maxresorb inject ; histology

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