Molecular docking study of a novel series of pyrazolines as potential inhibitors of phosphodiesterase type 5 (PDE5) (CROSBI ID 675382)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Rastija, Vesna ; Molnar, Maja ; Brahmbhatt, Harshad
engleski
Molecular docking study of a novel series of pyrazolines as potential inhibitors of phosphodiesterase type 5 (PDE5)
Phosphodiesterase type 5 (PDE5) is a cyclic guanosine monophosphate (cGMP)-specific enzyme and mostly expressed in smooth muscle tissue of corpus cavernosum, heart, lung, platelets, prostate, urethra, bladder, liver, brain, and stomach. Inhibitors of PDE5, prevent the hydrolysis of cGMP and become effective treatment to diseases associated with low cGMP level, such as pulmonary arterial hypertension. [1] It has been well-documented that pyrazole- containing compounds diverse chemotherapeutic potentials, such as antileukemic and antiproliferative agents. Beside, halogenated organic compounds has been widely use as many drug candidates. [2] Recently, we have synthesized a novel series of halogenated pyrazolines. Molecular docking study was performed to explain in silico the binding interaction with the PDE5 (PDB: 4oew). Molecular docking has confirmed that compound 5-(2, 6-dimethoxyphenyl)-3-(4-fluorophenyl)-4, 5-dihydro-1H-pyrazole-1-carbaldehyde has lowest total energy binding (-105, 69 kcal/mol). The binding interactions of the most active compound have shown strong hydrogen bonding and van der Waals interactions with the target protein.
pyrazolines ; phosphodiesterase ; molecular docking
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Podaci o prilogu
152-152.
2019.
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts, 26th Croatian Meeting of Chemists and Chemical Engineers
Galić, Nives ; Rogošić, Marko
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
978953689467-3
Podaci o skupu
26. hrvatski skup kemičara i kemijskih inženjera (26HSKIKI) ; 4. simpozij Vladimir Prelog
poster
09.04.2019-12.04.2019
Šibenik, Hrvatska