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Pregled bibliografske jedinice broj: 997412

Comparable Genomic Copy Number Aberrations Differ across Astrocytoma Malignancy Grades


Pecina-Slaus, Nives; Kafka, Anja; Gotovac Jercic, Kristina; Logara, Monika; Bukovac, Anja; Bakaric, Robert: Borovecki, Fran
Comparable Genomic Copy Number Aberrations Differ across Astrocytoma Malignancy Grades // International journal of molecular sciences, 20 (2019), 5; 1251, 25 doi:10.3390/ijms20051251 (međunarodna recenzija, članak, znanstveni)


Naslov
Comparable Genomic Copy Number Aberrations Differ across Astrocytoma Malignancy Grades

Autori
Pecina-Slaus, Nives ; Kafka, Anja ; Gotovac Jercic, Kristina ; Logara, Monika ; Bukovac, Anja ; Bakaric, Robert: Borovecki, Fran

Izvornik
International journal of molecular sciences (1422-0067) 20 (2019), 5; 1251, 25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Astrocytoma ; aCGH ; comparative genomic hybridization ; copy number aberrations ; GISTIC2.0.23

Sažetak
A collection of intracranial astrocytomas of different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were analyzed by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Genomic Identification of Significant Targets in Cancer (GISTIC) 2.0.23 and DAVID software. Altogether, 1438 CNA were found of which losses prevailed. On our total sample, significant deletions affected 14 chromosomal regions, out of which deletions at 17p13.2, 9p21.3, 13q12.11, 22q12.3 remained significant even at 0.05 q-value. When divided into malignancy groups, the regions identified as significantly deleted in high grades were: 9p21.3 ; 17p13.2 ; 10q24.2 ; 14q21.3 ; 1p36.11 and 13q12.11, while amplified were: 3q28 ; 12q13.3 and 21q22.3. Low grades comprised significant deletions at 3p14.3 ; 11p15.4 ; 15q15.1 ; 16q22.1 ; 20q11.22 and 22q12.3 indicating their involvement in early stages of tumorigenesis. Significantly enriched pathways were: PI3K-Akt, Cytokine-cytokine receptor, the nucleotide- binding oligomerization domain (NOD)⁻like receptor, Jak-STAT, retinoic acid-inducible gene (RIG)-I-like receptor and Toll-like receptor pathways. HPV and herpex simplex infection and inflammation pathways were also represented. The present study brings new data to astrocytoma research amplifying the wide spectrum of changes that could help us identify the regions critical for tumorigenesis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
GA KK01.1.1.01.0007
HRZZ-IP-2013-11-6625 - Uloga signalnog puta Wnt u epitelno-mezenhimskoj tranziciji (Nives Pećina-Šlaus, )
HRZZ-IP-2013-11-9386 - Genetski mehanizmi lizosomalne disfunkcije u Parkinsonovoj bolesti (Fran Borovečki, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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