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Pregled bibliografske jedinice broj: 997336

How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions


Wetmore, Stacey D.; Smith, David M.; Radom, Leo
How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions // Journal of the American Chemical Society, 122 (2000), 41; 10208-10209 doi:10.1021/ja001651y (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 997336 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions

Autori
Wetmore, Stacey D. ; Smith, David M. ; Radom, Leo

Izvornik
Journal of the American Chemical Society (0002-7863) 122 (2000), 41; 10208-10209

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
METHYLMALONYL-COA MUTASE ; PARTIAL-PROTON-TRANSFER ; MECHANISM ; ADENOSYLCOBALAMIN ; REARRANGEMENT

Sažetak
The 1, 2-shift of an amino group appears to be a demanding task. Our calculations show that the rearrangement may be efficiently accomplished as a result of an intricate relationship between the enzyme and its cofactors. Thus, we believe that coenzyme B12 is responsible for activating the substrate by removal of a hydrogen atom. Vitamin B6 (PLP) introduces a seemingly essential double bond into the migrating group, as well as imparting the potential for the reaction intermediate to be captodatively stabilized. The enzyme itself holds all the components in place and provides an environment in which the pyridine nitrogen can be fully (or partially) protonated. This cooperative action of the enzyme and cofactors is able to mediate an otherwise difficult reaction.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Profili:

Avatar Url David Matthew Smith (autor)

Citiraj ovu publikaciju

Wetmore, Stacey D.; Smith, David M.; Radom, Leo
How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions // Journal of the American Chemical Society, 122 (2000), 41; 10208-10209 doi:10.1021/ja001651y (međunarodna recenzija, članak, znanstveni)
Wetmore, S., Smith, D. & Radom, L. (2000) How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions. Journal of the American Chemical Society, 122 (41), 10208-10209 doi:10.1021/ja001651y.
@article{article, year = {2000}, pages = {10208-10209}, DOI = {10.1021/ja001651y}, keywords = {METHYLMALONYL-COA MUTASE, PARTIAL-PROTON-TRANSFER, MECHANISM, ADENOSYLCOBALAMIN, REARRANGEMENT}, journal = {Journal of the American Chemical Society}, doi = {10.1021/ja001651y}, volume = {122}, number = {41}, issn = {0002-7863}, title = {How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions}, keyword = {METHYLMALONYL-COA MUTASE, PARTIAL-PROTON-TRANSFER, MECHANISM, ADENOSYLCOBALAMIN, REARRANGEMENT} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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