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How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions (CROSBI ID 263848)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Wetmore, Stacey D. ; Smith, David M. ; Radom, Leo How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions // Journal of the American Chemical Society, 122 (2000), 41; 10208-10209. doi: 10.1021/ja001651y

Podaci o odgovornosti

Wetmore, Stacey D. ; Smith, David M. ; Radom, Leo

engleski

How B-6 helps B-12: The roles of B-6, B-12, and the enzymes in aminomutase-catalyzed reactions

The 1, 2-shift of an amino group appears to be a demanding task. Our calculations show that the rearrangement may be efficiently accomplished as a result of an intricate relationship between the enzyme and its cofactors. Thus, we believe that coenzyme B12 is responsible for activating the substrate by removal of a hydrogen atom. Vitamin B6 (PLP) introduces a seemingly essential double bond into the migrating group, as well as imparting the potential for the reaction intermediate to be captodatively stabilized. The enzyme itself holds all the components in place and provides an environment in which the pyridine nitrogen can be fully (or partially) protonated. This cooperative action of the enzyme and cofactors is able to mediate an otherwise difficult reaction.

METHYLMALONYL-COA MUTASE ; PARTIAL-PROTON-TRANSFER ; MECHANISM ; ADENOSYLCOBALAMIN ; REARRANGEMENT

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Podaci o izdanju

122 (41)

2000.

10208-10209

objavljeno

0002-7863

10.1021/ja001651y

Povezanost rada

Kemija

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