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Synthesis and antimicrobial potential of bisquaternary ammonium compounds based on quinuclidine-3-ol

Quaternary ammonium compounds (QACs), as cationic amphiphiles, show broad-spectrum antibacterial activity due to a mechanism based on membrane disruption. Since previously synthesized monoQACs containing quinuclidine-3- ol showed promising antimicrobial potential, we have further developed a new series of bisQACs containing quinuclidine-3-ol. In this series, we bind two quinuclidine centers by long alkyl chains of variable length (C8, C10 and C12), assuming that two-headed (bicephalic) QACs would possess even better ability of bacterial membrane disruption. These compounds were screened for antimicrobial activity against Gram-positive and Gram- negative bacterial strains, both ATCC and clinical isolates, as well as fungi and molds. Activity toward inhibition of the biofilm structures and cytotoxicity were also tested.

Quaternary ammonium compounds (QAC) ; BisQACs ; Antimicrobial activity ; Cytotoxicity

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