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Pregled bibliografske jedinice broj: 995417

Centromere of the nematode Meloidogyne ; characterization of centromere specific H3 protein (CENH3) and underlying DNA sequences


Despot Slade, Evelin; Pavlek, Martina; Mravinac, Brankica; Castagnone-Sereno, Phillipe; Plohl, Miroslav; Meštrović, Nevenka
Centromere of the nematode Meloidogyne ; characterization of centromere specific H3 protein (CENH3) and underlying DNA sequences // Molecular Biophysics: ABC of the puzzle of Life / Ivošević DeNardis, Nadica ; Campos-Olivas, Ramon ; Miele Adriana E. ; England, Patrick ; Vuletić, Tomislav (ur.).
Zagreb, Hrvatska: Ruđer Bošković Institute and Croatian Biophysical Society, 2019. str. 82-82 (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Centromere of the nematode Meloidogyne ; characterization of centromere specific H3 protein (CENH3) and underlying DNA sequences

Autori
Despot Slade, Evelin ; Pavlek, Martina ; Mravinac, Brankica ; Castagnone-Sereno, Phillipe ; Plohl, Miroslav ; Meštrović, Nevenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Molecular Biophysics: ABC of the puzzle of Life / Ivošević DeNardis, Nadica ; Campos-Olivas, Ramon ; Miele Adriana E. ; England, Patrick ; Vuletić, Tomislav - : Ruđer Bošković Institute and Croatian Biophysical Society, 2019, 82-82

ISBN
978-953-7941-28-4

Skup
3rd COST-sponsored ARBRE-MOBIEU plenary meeting, Molecular Biophysics: ABC of the puzzle of Life

Mjesto i datum
Zagreb, Hrvatska, 18-20.03.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
centromere ; CENH3 ; nematode

Sažetak
Centromeres are chromosomal domains essential for proper segregation of genetic material in cell divisions. They are defined epigenetically by the presence of centromere-specific histone H3 protein (CENH3). CENH3 histone is a species-specific protein, particularly variable in its N-terminal domain which is associated with centromeric DNA. In contrast to conserved function of the centromere, CENH3 and centromeric DNA evolve rapidly in diverse organisms. Why the centromere is composed of unstable units is still unsolved question. Nematodes Meloidogyne have some exceptional characteristics, such as presumptive holocentric organization of the centromere and specific mode of reproduction by mitotic parthenogenesis, which make them an ideal system to study centromere structure and function. Interestingly, our genome analysis of centromere protein CENH3 in Meloidogyne incognita reveal three divergent genes for CENH3 (α, β, λ), which are completely conserved in its related species. Transcriptome data show developmental stage-specific expression of CENH3 variants. Immunostaining of chromosomes with antibodies specific for αCENH3 reveals so far unseen distribution of CENH3 in forms of monocentric, dicentric, polycentric and holocentric centromeres. ChIP experiments suggested that different repetitive sequences with conserved 21-nt motif may be associated with αCENH3 domains.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-3183 - Centromerna genomika beskralježnjaka (Miroslav Plohl, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Despot Slade, Evelin; Pavlek, Martina; Mravinac, Brankica; Castagnone-Sereno, Phillipe; Plohl, Miroslav; Meštrović, Nevenka
Centromere of the nematode Meloidogyne ; characterization of centromere specific H3 protein (CENH3) and underlying DNA sequences // Molecular Biophysics: ABC of the puzzle of Life / Ivošević DeNardis, Nadica ; Campos-Olivas, Ramon ; Miele Adriana E. ; England, Patrick ; Vuletić, Tomislav (ur.).
Zagreb, Hrvatska: Ruđer Bošković Institute and Croatian Biophysical Society, 2019. str. 82-82 (poster, domaća recenzija, sažetak, znanstveni)
Despot Slade, E., Pavlek, M., Mravinac, B., Castagnone-Sereno, P., Plohl, M. & Meštrović, N. (2019) Centromere of the nematode Meloidogyne ; characterization of centromere specific H3 protein (CENH3) and underlying DNA sequences. U: Ivošević DeNardis, N., Campos-Olivas, R., Miele Adriana E., England, P. & Vuletić, T. (ur.)Molecular Biophysics: ABC of the puzzle of Life.
@article{article, year = {2019}, pages = {82-82}, keywords = {centromere, CENH3, nematode}, isbn = {978-953-7941-28-4}, title = {Centromere of the nematode Meloidogyne ; characterization of centromere specific H3 protein (CENH3) and underlying DNA sequences}, keyword = {centromere, CENH3, nematode}, publisher = {Ru\djer Bo\v{s}kovi\'{c} Institute and Croatian Biophysical Society}, publisherplace = {Zagreb, Hrvatska} }