Mapping and predicting mortality from systemic sclerosis (CROSBI ID 263308)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Elhai, Muriel ; Meune, Christophe ; Boubaya, Marouane ; Avouac, Jérôme ; Hachulla, Eric ; Balbir-Gurman, Alexandra ; Riemekasten, Gabriela ; Airò, Paolo ; Joven, Beatriz ; Vettori, Serena ; Cozzi, Franco ; Ullman, Susanne ; Czirják, László ; Tikly, Mohammed ; Müller-Ladner, Ulf ; Caramaschi, Paola ; Distler, Oliver ; Iannone, Florenzo ; Ananieva, Lidia P ; Hesselstrand, Roger ; Becvar, Radim ; Gabrielli, Armando ; Damjanov, Nemanja ; Salvador, Maria J ; Riccieri, Valeria ; Mihai, Carina ; Szücs, Gabriella ; Walker, Ulrich A ; Hunzelmann, Nicolas ; Martinovic, Duska ; Smith, Vanessa ; Müller, Carolina de Souza ; Montecucco, Carlo Maurizio ; Opris, Daniela ; Ingegnoli, Francesca ; Vlachoyiannopoulos, Panayiotis G ; Stamenkovic, Bojana ; Rosato, Edoardo ; Heitmann, Stefan ; Distler, Jörg H W ; Zenone, Thierry ; Seidel, Matthias ; Vacca, Alessandra ; Langhe, Ellen De ; Novak, Srdan ; Cutolo, Maurizio ; Mouthon, Luc ; Henes, Jörg ; Chizzolini, Carlo ; Mühlen, Carlos Alberto von ; Solanki, Kamal ; Rednic, Simona ; Stamp, Lisa ; Anic, Branimir ; Santamaria, Vera Ortiz ; Santis, Maria De ; Yavuz, Sule ; Sifuentes-Giraldo, Walter Alberto ; Chatelus, Emmanuel ; Stork, Jiri ; Laar, Jacob van ; Loyo, Esthela ; García de la Peña Lefebvre, Paloma ; Eyerich, Kilian ; Cosentino, Vanesa ; Alegre-Sancho, Juan Jose ; Kowal-Bielecka, Otylia ; Rey, Grégoire ; Matucci-Cerinic, Marco ; Allanore, Yannick
EUSTAR Coauthors
engleski
Mapping and predicting mortality from systemic sclerosis
OBJECTIVES: To determine the causes of death and risk factors in systemic sclerosis (SSc). METHODS: Between 2000 and 2011, we examined the death certificates of all French patients with SSc to determine causes of death. Then we examined causes of death and developed a score associated with all-cause mortality from the international European Scleroderma Trials and Research (EUSTAR) database. Candidate prognostic factors were tested by Cox proportional hazards regression model by single variable analysis, followed by a multiple variable model stratified by centres. The bootstrapping technique was used for internal validation. RESULTS: We identified 2719 French certificates of deaths related to SSc, mainly from cardiac (31%) and respiratory (18%) causes, and an increase in SSc-specific mortality over time. Over a median follow-up of 2.3 years, 1072 (9.6%) of 11 193 patients from the EUSTAR sample died, from cardiac disease in 27% and respiratory causes in 17%. By multiple variable analysis, a risk score was developed, which accurately predicted the 3-year mortality, with an area under the curve of 0.82. The 3-year survival of patients in the upper quartile was 53%, in contrast with 98% in the first quartile. CONCLUSION: Combining two complementary and detailed databases enabled the collection of an unprecedented 3700 deaths, revealing the major contribution of the cardiopulmonary system to SSc mortality. We also developed a robust score to risk-stratify these patients and estimate their 3-year survival. With the emergence of new therapies, these important observations should help caregivers plan and refine the monitoring and management to prolong these patients' survival.
cardiovascular disease ; epidemiology ; pulmonary fibrosis ; systemic sclerosis
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
76 (11)
2017.
1897-1905
objavljeno
0003-4967
1468-2060
10.1136/annrheumdis-2017-211448
Povezanost rada
Kliničke medicinske znanosti