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Pregled bibliografske jedinice broj: 993892

Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells


Horvat, Luka; Grubar, Martina; Madunić, Josip; Antica, Mariastefania; Matulić, Maja
Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells // Molecular and Experimental Biology in Medicine, 2 (2019), 1; 38-43 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 993892 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells

Autori
Horvat, Luka ; Grubar, Martina ; Madunić, Josip ; Antica, Mariastefania ; Matulić, Maja

Izvornik
Molecular and Experimental Biology in Medicine (2584-671X) 2 (2019), 1; 38-43

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
differentiation ; retinoic acid ; SH-SY5Y ; PARP

Sažetak
Differentiation is a complex process by which cells become specialized in their physiological functions. As this process is followed by a decrease in proliferation ability, the induction of differentiation could be an ideal cancer treatment. We analyzed the effects of a common differentiation agent, retinoic acid, on neuroblastoma SH-SY5Y cells under the conditions of poly(ADP-ribose) polymerase (PARP) inhibition. Namely, PARP1 can be indirectly involved in processes of chromatin remodelling, so the aim was to investigate whether its inhibition can influence the process of differentiation. Cells differentiated after retinoic acid treatment into neural cells, with neurite outgrowth, proliferation arrest and induction of tissue plasminogen activator. PARP inhibition did not influence the process of differentiation. Analysis of gene expression revealed the involvement of several signaling pathways in RA-dependent differentiation. Beside TGFβ and Notch pathways, master transcription factors directing epithelial-mesenchymal transition were shown to also take part in the differentiation process.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-7140 - Notch u diferencijaciji hematopoetskih stanica matica i u razvoju leukemija (Mariastefania Antica, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Avatar Url Maja Matulić (autor)

Avatar Url Josip Madunić (autor)

Avatar Url Luka Horvat (autor)

Citiraj ovu publikaciju

Horvat, Luka; Grubar, Martina; Madunić, Josip; Antica, Mariastefania; Matulić, Maja
Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells // Molecular and Experimental Biology in Medicine, 2 (2019), 1; 38-43 (međunarodna recenzija, članak, znanstveni)
Horvat, L., Grubar, M., Madunić, J., Antica, M. & Matulić, M. (2019) Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells. Molecular and Experimental Biology in Medicine, 2 (1), 38-43.
@article{article, year = {2019}, pages = {38-43}, keywords = {differentiation, retinoic acid, SH-SY5Y, PARP}, journal = {Molecular and Experimental Biology in Medicine}, volume = {2}, number = {1}, issn = {2584-671X}, title = {Inhibition of PARP activity does not affect the differentiation processes caused by retinoic acid in SH-SY5Y cells}, keyword = {differentiation, retinoic acid, SH-SY5Y, PARP} }