engleski

The Role Of Matrix Metalloproteinases (MMPS) In The Female Reproductive System - Review Article

Matrix metalloproteinases comprise of several endopeptidases which have certain roles in physiological and pathological processes within various body parts. It has been suggested that their role is very important in endometriosis, recurrent implant failure, infertility and even gynecological malignancies. Therefore, we searched Pubmed in order to summarize already known data upon MMPs within female genital tract and 48 articles were included. It seems that matrix metalloproteinases might have role in the treatment of endometriosis and recurrent implantation failure as well as they could serve as markers in women with gynecological malignancies. However, there is a wide heterogeneity among so far published studies and results, and also among applied techniques. Further research of the role of specific MMPs is needed to verify the results.

matrix metalloproteinases ; endopeptidases ; markers ; female reproductive system ; gynecological health

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