Choline chloride based deep eutectic solvents as a tuneable media for synthesis of coumarinyl 1, 2, 4‐triazoles: effect of solvent type and temperature (CROSBI ID 262069)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Molnar, Maja ; Periš, Ivana ; Komar, Mario
engleski
Choline chloride based deep eutectic solvents as a tuneable media for synthesis of coumarinyl 1, 2, 4‐triazoles: effect of solvent type and temperature
A study of 1, 2, 4‐triazoles synthesis from 2‐ ((4‐methyl‐2‐oxo‐2H‐chromen‐7‐ yl)oxy)acetohydrazide (1) or 2‐(7‐hydroxy‐2‐ oxo‐ 2H‐chromen‐4‐yl)acetohydrazide (2) and various isothiocyanates, in deep eutectic solvents was performed. In order to find the best conditions for 1, 2, 4‐triazole formation, a model reaction on 1 and phenylisothiocyanate was performed in 14 different choline chloride based deep eutectic solvents, at two different temperatures (40°C and 80°C). Pure 1, 2, 4‐ triazoles were obtained in choline chloride:urea (1:2) and choline chloride:N‐ methyl urea (1:3) deep eutectic solvents at 80°C. Pure thiosemicarbazides were obtained in choline chloride:ethane‐1, 2‐diol (1:2), choline chloride:malic acid (1:1), choline chloride:malonic acid (1:1), choline chloride:butane‐1, 4‐diol (1:3) and choline chloride:glycerole (1:2) at 40°C. The ratio of 1, 2, 4‐triazoles and thiosemicarbazides in reaction mixtures was determined by HPLC and 1H NMR. After the best conditions for 1, 2, 4‐ triazole synthesis were found, a some coumarinyl 1, 2, 4‐ triazoles were synthesized from two different coumarinyl hydrazides (1 and 2) and various alkyl and aryl isothiocyanates in one step reaction.
deep eutectic solvents ; coumarins ; 1, 2, 4-triazole ; thiosemicarbazide
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
2019 (15)
2019.
2688-2694
objavljeno
1434-193X
1099-0690
10.1002/ejoc.201900249