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Pregled bibliografske jedinice broj: 990916

Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer


Novak Kujundžić, Renata; Stepanić, Višnja; Milković, Lidija; Čipak Gašparović, Ana; Tomljanović, Marko; Gall-Trošelj, Koraljka
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer // International journal of molecular sciences, 20 (2019), 5; 1180, 24 doi:10.3390/ijms20051180 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Curcumin and its Potential for Systemic Targeting of Inflamm-Aging and Metabolic Reprogramming in Cancer

Autori
Novak Kujundžić, Renata ; Stepanić, Višnja ; Milković, Lidija ; Čipak Gašparović, Ana ; Tomljanović, Marko ; Gall-Trošelj, Koraljka

Izvornik
International journal of molecular sciences (1422-0067) 20 (2019), 5; 1180, 24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Curcumin ; oxidative metabolites ; inflamm-aging ; cancer ; metabolic reprogramming ; direct protein binding ; IL-17 ; STAT3 ; SHMT2

Sažetak
Pleiotropic effects of curcumin have been the subject of intensive research. The interest in this molecule for preventive medicine may further increase because of its potential to modulate inflamm-aging. Although direct data related to its effect on inflamm-aging does not exist, there is a strong possibility that its well-known anti- inflammatory properties may be relevant to this phenomenon. Curcumin’s binding to various proteins, which was shown to be dependent on cellular oxidative status, is yet another feature for exploration in depth. Finally, the binding of curcumin to various metabolic enzymes is crucial to curcumin’s interference with powerful metabolic machinery, and can also be crucial for metabolic reprogramming of cancer cells. This review offers a synthesis and functional links that may better explain older data, some observational, in light of the most recent findings on curcumin. Our focus is on its modes of action that have the potential to alleviate specific morbidities of the 21st century.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2016-06-4404 - NRF2 na raskrižju epigenetičkog modeliranja, metabolizma i proliferacije stanice raka (Koraljka Gall Trošelj, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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