First total synthesis of ent-asperparaline C and assignment of the absolute configuration of asperparaline C (CROSBI ID 261863)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dokli, Irena ; Pohl, Radek ; Klepetářová, Blanka ; Jahn, Ullrich
engleski
First total synthesis of ent-asperparaline C and assignment of the absolute configuration of asperparaline C
The first asymmetric total synthesis of a member of the asperparaline family was accomplished and the unknown absolute configuration of asperparaline C has been determined to be all-(S). The key steps of the synthesis are an oxidative radical cyclization, a selective reduction of one of the tertiary amides, a singlet oxygen Diels–Alder reaction and a reductive spirocyclization.
Asperparaline C ; Total synthesis ; Absolute configuration ; Alkaloids ; Radical cyclization
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