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The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape (vol 25, pg 2518, 2015)


Busby, George B.J.; Hellenthal, Garrett; Montinaro, Francesco; Tofanelli, Sergio; Bulayeva, Kazima; Rudan, Igor; Zemunik, Tatijana; Hayward, Caroline; Toncheva, Draga; Karachanak-Yankova, Sena et al.
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape (vol 25, pg 2518, 2015) // Current Biology, 25 (2015), 21; 2518-2526 doi:10.1016/j.cub.2015.10.037 (podatak o recenziji nije dostupan, ispravak, znanstveni)


Naslov
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape (vol 25, pg 2518, 2015)

Autori
Busby, George B.J. ; Hellenthal, Garrett ; Montinaro, Francesco ; Tofanelli, Sergio ; Bulayeva, Kazima ; Rudan, Igor ; Zemunik, Tatijana ; Hayward, Caroline ; Toncheva, Draga ; Karachanak-Yankova, Sena ; Nesheva, Desislava ; Anagnostou, Paolo ; Cali, Francesco ; Brisighelli, Francesca ; Romano, Valentino ; Lefranc, Gerard ; Buresi, Catherine ; Ben Chibani, Jemni ; Haj-Khelil, Amel ; Denden, Sabri ; Ploski, Rafal ; Krajewski, Pawel ; Hervig, Tor ; Moen, Torolf ; Herrera, Rene J. ; Wilson, James F. ; Myers, Simon ; Capelli, Cristian

Izvornik
Current Biology (0960-9822) 25 (2015), 21; 2518-2526

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ispravak, znanstveni

Ključne riječi
POPULATION-STRUCTURE ; GENETIC DIVERSITY ; EUROPE ; ANCESTRY ; HISTORY ; ASSOCIATION ; ORIGINS

Sažetak
Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-scale, dynamic population movements over the last 10, 000 years, such that ancestry across present-day populations is likely to be a mixture of several ancient groups [1-7]. While these efforts are bringing the details of West Eurasian prehistory into increasing focus, studies aimed at understanding the processes behind the generation of the current West Eurasian genetic landscape have been limited by the number of populations sampled or have been either too regional or global in their outlook [8-11]. Here, using recently described haplotype-based techniques [11], we present the results of a systematic survey of recent admixture history across Western Eurasia and show that admixture is a universal property across almost all groups. Admixture in all regions except North Western Europe involved the influx of genetic material from outside of West Eurasia, which we date to specific time periods. Within Northern, Western, and Central Europe, admixture tended to occur between local groups during the period 300 to 1200 CE. Comparisons of the genetic profiles of West Eurasians before and after admixture show that population movements within the last 1, 500 years are likely to have maintained differentiation among groups. Our analysis provides a timeline of the gene flow events that have generated the contemporary genetic landscape of West Eurasia.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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