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Pregled bibliografske jedinice broj: 990343

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration


de Vries, Paul S.; Chasman, Daniel I.; Sabater-Lleal, Maria; Chen, Ming-Huei; Huffman, Jennifer E.; Steri, Maristella; Tang, Weihong; Teumer, Alexander; Marioni, Riccardo E.; Grossmann, Vera et al.
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration // Human Molecular Genetics, 25 (2016), 2; 358-370 doi:10.1093/hmg/ddv454 (međunarodna recenzija, članak, znanstveni)


Naslov
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

Autori
De Vries, Paul S. ; Chasman, Daniel I. ; Sabater-Lleal, Maria ; Chen, Ming-Huei ; Huffman, Jennifer E. ; Steri, Maristella ; Tang, Weihong ; Teumer, Alexander ; Marioni, Riccardo E. ; Grossmann, Vera ; Hottenga, Jouke J. ; Trompet, Stella ; Müller-Nurasyid, Martina ; Zhao, Jing Hua ; Brody, Jennifer A. ; Kleber, Marcus E. ; Guo, Xiuqing ; Wang, Jie Jin ; Auer, Paul L. ; Attia, John R. ; Yanek, Lisa R. ; Ahluwalia, Tarunveer S. ; Lahti, Jari ; Venturini, Cristina ; Tanaka, Toshiko ; Bielak, Lawrence F. ; Joshi, Peter K. ; Rocanin-Arjo, Ares ; Kolcic, Ivana ; Navarro, Pau ; Rose, Lynda M. ; Oldmeadow, Christopher ; Riess, Helene ; Mazur, Johanna ; Basu, Saonli ; Goel, Anuj ; Yang, Qiong ; Ghanbari, Mohsen ; Willemsen, Gonneke ; Rumley, Ann ; Fiorillo, Edoardo ; de Craen, Anton J. M. ; Grotevendt, Anne ; Scott, Robert ; Taylor, Kent D. ; Delgado, Graciela E. ; Yao, Jie ; Kifley, Annette ; Kooperberg, Charles ; Qayyum, Rehan ; Lopez, Lorna M. ; Berentzen, Tina L. ; Räikkönen, Katri ; Mangino, Massimo ; Bandinelli, Stefania ; Peyser, Patricia A. ; Wild, Sarah ; Trégouët, David-Alexandre ; Wright, Alan F. ; Marten, Jonathan ; Zemunik, Tatijana ; Morrison, Alanna C. ; Sennblad, Bengt ; Tofler, Geoffrey ; de Maat, Moniek P. M. ; de Geus, Eco J. C. ; Lowe, Gordon D. ; Zoledziewska, Magdalena ; Sattar, Naveed ; Binder, Harald ; Völker, Uwe ; Waldenberger, Melanie ; Khaw, Kay-Tee ; Mcknight, Barbara ; Huang, Jie ; Jenny, Nancy S. ; Holliday, Elizabeth G. ; Qi, Lihong ; Mcevoy, Mark G. ; Becker, Diane M. ; Starr, John M. ; Sarin, Antti-Pekka ; Hysi, Pirro G. ; Hernandez, Dena G. ; Jhun, Min A. ; Campbell, Harry ; Hamsten, Anders ; Rivadeneira, Fernando ; Mcardle, Wendy L. ; Slagboom, P. Eline ; Zeller, Tanja ; Koenig, Wolfgang ; Psaty, Bruce M. ; Haritunians, Talin ; Liu, Jingmin ; Palotie, Aarno ; Uitterlinden, André G. ; Stott, David J. ; Hofman, Albert ; Franco, Oscar H. ; Polasek, Ozren ; Rudan, Igor ; Morange, Pierre-Emmanuel ; Wilson, James F. ; Kardia, Sharon L. R. ; Ferrucci, Luigi ; Spector, Tim D. ; Eriksson, Johan G. ; Hansen, Torben ; Deary, Ian J. ; Becker, Lewis C. ; Scott, Rodney J. ; Mitchell, Paul ; März, Winfried ; Wareham, Nick J. ; Peters, Annette ; Greinacher, Andreas ; Wild, Philipp S. ; Jukema, J. Wouter ; Boomsma, Dorret I. ; Hayward, Caroline ; Cucca, Francesco ; Tracy, Russell ; Watkins, Hugh ; Reiner, Alex P. ; Folsom, Aaron R. ; Ridker, Paul M. ; O'Donnell, Christopher J. ; Smith, Nicholas L. ; Strachan, David P. ; Dehghan, Abbas

Izvornik
Human Molecular Genetics (0964-6906) 25 (2016), 2; 358-370

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GENOME-WIDE ASSOCIATION ; C-REACTIVE PROTEIN ; CARDIOVASCULAR-DISEASE ; CIRCULATING FIBRINOGEN ; GENETIC ARCHITECTURE ; VARIANTS ; DESIGN ; HEMOSTASIS ; RESOURCE ; HEALTH

Sažetak
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including similar to 120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci ; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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