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Pregled bibliografske jedinice broj: 990336

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits


Evangelou, Evangelos; the Million Veteran Program; Warren, Helen R.; Mosen-Ansorena, David; Kolcic, Ivana; Polasek, Ozren; Pramstaller, Peter P.; Nguyen, Quang Tri; Raitakari, Olli T.; Ren, Meixia et al.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits // Nature Genetics, 50 (2018), 10; 1412-1425 doi:10.1038/s41588-018-0205-x (međunarodna recenzija, članak, znanstveni)


Naslov
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Autori
Evangelou, Evangelos ; the Million Veteran Program ; Warren, Helen R. ; Mosen-Ansorena, David ; Kolcic, Ivana ; Polasek, Ozren ; Pramstaller, Peter P. ; Nguyen, Quang Tri ; Raitakari, Olli T. ; Ren, Meixia ; Rettig, Rainer ; Rice, Kenneth ; Ridker, Paul M. ; Ried, Janina S. ; Riese, Harriëtte ; Ripatti, Samuli ; Robino, Antonietta ; Rose, Lynda M. ; Rotter, Jerome I. ; Rudan, Igor ; Zemunik, Tatijana et al.

Izvornik
Nature Genetics (1061-4036) 50 (2018), 10; 1412-1425

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GENOME-WIDE ASSOCIATION ; CARDIOVASCULAR-DISEASE RISK ; UK BIOBANK ; HYPERTENSION ; VARIANTS ; METAANALYSIS ; COMMON ; HEALTH ; RARE ; HYPERALDOSTERONISM

Sažetak
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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