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Pregled bibliografske jedinice broj: 989826

The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology


Jazvinšćak Jembrek, Maja; Newberg, Kety; Šimić, Goran
The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology // Pathology, Prevention and Therapeutics of Neurodegenerative Disease / Singh, Sarika ; Joshi, Neeraj (ur.).
Singapore: Springer, 2019. str. 39-48 doi:10.1007/978-981-13-0944-1_4


CROSBI ID: 989826 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology

Autori
Jazvinšćak Jembrek, Maja ; Newberg, Kety ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Pathology, Prevention and Therapeutics of Neurodegenerative Disease

Urednik/ci
Singh, Sarika ; Joshi, Neeraj

Izdavač
Springer

Grad
Singapore

Godina
2019

Raspon stranica
39-48

ISBN
978-981-13-0943-4

Ključne riječi
p53 ; tau pathology ; amyloid β ; Alzheimer’s disease

Sažetak
Extracellular accumulation of amyloid β peptide and intraneuronal deposition of hyperphosphorylated tau protein are defining clinico-pathological characteristics of Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder. Levels of transcription factor p53, which plays an important role in oxidative stress-induced apoptosis, are also found up-regulated in AD brain. We briefly summarized the major p53-mediated molecular events that contribute to pathological changes in AD, with special emphasis on the progression of tau pathology.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-9730 - Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva (ALZTAUPROTECT) (HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Hrvatsko katoličko sveučilište, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.springer.com link.springer.com

Citiraj ovu publikaciju:

Jazvinšćak Jembrek, Maja; Newberg, Kety; Šimić, Goran
The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology // Pathology, Prevention and Therapeutics of Neurodegenerative Disease / Singh, Sarika ; Joshi, Neeraj (ur.).
Singapore: Springer, 2019. str. 39-48 doi:10.1007/978-981-13-0944-1_4
Jazvinšćak Jembrek, M., Newberg, K. & Šimić, G. (2019) The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology. U: Singh, S. & Joshi, N. (ur.) Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Singapore, Springer, str. 39-48 doi:10.1007/978-981-13-0944-1_4.
@inbook{inbook, author = {Jazvin\v{s}\'{c}ak Jembrek, Maja and Newberg, Kety and \v{S}imi\'{c}, Goran}, year = {2019}, pages = {39-48}, DOI = {10.1007/978-981-13-0944-1\_4}, keywords = {p53, tau pathology, amyloid β, Alzheimer’s disease}, doi = {10.1007/978-981-13-0944-1\_4}, isbn = {978-981-13-0943-4}, title = {The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology}, keyword = {p53, tau pathology, amyloid β, Alzheimer’s disease}, publisher = {Springer}, publisherplace = {Singapore} }
@inbook{inbook, author = {Jazvin\v{s}\'{c}ak Jembrek, Maja and Newberg, Kety and \v{S}imi\'{c}, Goran}, year = {2019}, pages = {39-48}, DOI = {10.1007/978-981-13-0944-1\_4}, keywords = {p53, tau pathology, amyloid β, Alzheimer’s disease}, doi = {10.1007/978-981-13-0944-1\_4}, isbn = {978-981-13-0943-4}, title = {The Role of p53 in Alzheimer’s Disease: Impact on Tau Pathology}, keyword = {p53, tau pathology, amyloid β, Alzheimer’s disease}, publisher = {Springer}, publisherplace = {Singapore} }

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